ARG1

Protein identityUniProt · HPA

UniProt accession

P05089

Gene

ARG1

Ensembl

ENSG00000118520

Chromosome

6

Canonical length

322 aa

Protein class

Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins

Quaternary structure

Homotrimer

OverviewNCBI Gene

Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

322 residues, UniProt reviewed canonical sequence.

>P05089|ARG1
     1  MSAKSRTIGI IGAPFSKGQP RGGVEEGPTV LRKAGLLEKL KEQECDVKDY GDLPFADIPN
    61  DSPFQIVKNP RSVGKASEQL AGKVAEVKKN GRISLVLGGD HSLAIGSISG HARVHPDLGV
   121  IWVDAHTDIN TPLTTTSGNL HGQPVSFLLK ELKGKIPDVP GFSWVTPCIS AKDIVYIGLR
   181  DVDPGEHYIL KTLGIKYFSM TEVDRLGIGK VMEETLSYLL GRKKRPIHLS FDVDGLDPSF
   241  TPATGTPVVG GLTYREGLYI TEEIYKTGLL SGLDIMEVNP SLGKTPEEVT RTVNTAVAIT
   301  LACFGLAREG NHKPIDYLNP PK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.22

Highest tissue expression

1,125 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ARG1.

Disease | AllUniProt

Conditions ARG1 is implicated in, by any mechanism.

• Argininemia (ARGIN) MIM:207800

Disease | GeneticClinVar

139 pathogenic / likely-pathogenic of 579 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Arginase deficiency
• ARG1-related disorder
• Inborn genetic diseases

Disease | ImmuneIEDB

Conditions an epitope on ARG1 was assayed in.

• breast cancer T cell
• skin melanoma T cell
• melanoma T cell
• rectum cancer T cell
• ovarian cancer T cell
• ocular melanoma T cell
• colon cancer T cell
• myeloproliferative neoplasm T cell
• multiple myeloma T cell
• polycythemia vera T cell
• essential thrombocythemia T cell
• myelofibrosis T cell
• renal cell carcinoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.92

gnomAD pLI

0

gnomAD missense Z

0.06

DepMap mean gene effect

0.18

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adaptive immune response
• defense response to protozoan
• innate immune response
• L-arginine catabolic process
• negative regulation of activated T cell proliferation
• negative regulation of T cell proliferation
• negative regulation of T-helper 2 cell cytokine production
• negative regulation of type II interferon-mediated signaling pathway
• response to nematode
• urea cycle
• positive regulation of neutrophil mediated killing of fungus

Molecular functions

• arginase activity
• manganese ion binding

Cellular components

• azurophil granule lumen
• cytoplasm
• cytosol
• extracellular region
• extracellular space
• nucleus
• specific granule lumen

Protein domainsUniProt · Pfam · InterPro

• Ureohydrolase
• Arginase
• Ureohydrolase, manganese-binding site
• Ureohydrolase domain superfamily
• Arginase family

KeywordsUniProt

• Adaptive immunity
• Arginine metabolism
• Cytoplasm
• Hydrolase
• Immunity
• Innate immunity
• Manganese
• Metal-binding
• Phosphoprotein
• Urea cycle

InteractionsUniProt · HPA

Protein binding partners of ARG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CMTM6