Seroatlas · Human Serome Atlas

CD58

Lymphocyte function-associated antigen 3

Also known as: LFA3, LFA3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P19256
Gene: CD58
Ensembl: ENSG00000116815
Chromosome: 1
Canonical length: 250 aa
Protein class: CD markers, Human disease related genes, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. The protein is localized to the plasma membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]

Canonical amino-acid sequenceUniProt

250 residues, UniProt reviewed canonical sequence.

>P19256|CD58
     1  MVAGSDAGRA LGVLSVVCLL HCFGFISCFS QQIYGVVYGN VTFHVPSNVP LKEVLWKKQK
    61  DKVAELENSE FRAFSSFKNR VYLDTVSGSL TIYNLTSSDE DEYEMESPNI TDTMKFFLYV
   121  LESLPSPTLT CALTNGSIEV QCMIPEHYNS HRGLIMYSWD CPMEQCKRNS TSIYFKMEND
   181  LPQKIQCTLS NPLFNTTSSI ILTTCIPSSG HSRHRYALIP IPLAVITTCI VLYMNGILKC
   241  DRKPDRTNSN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD58 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 55 nTPM
heart muscle: 33 nTPM
blood vessel: 28 nTPM
small intestine: 28 nTPM
urinary bladder: 28 nTPM
lung: 27 nTPM

Single-cell type

neutrophils: 768 nCPM
cdc: 403 nCPM
monocytes: 328 nCPM
ocular epithelial cells: 221 nCPM
macrophages: 219 nCPM
neutrophil progenitors: 202 nCPM

Immune cell

neutrophil: 167 nTPM
basophil: 134 nTPM
eosinophil: 90 nTPM
non-classical monocyte: 65 nTPM
T-reg: 65 nTPM
intermediate monocyte: 51 nTPM

Brain region

white matter: 12 nTPM
choroid plexus: 12 nTPM
medulla oblongata: 10 nTPM
thalamus: 9.9 nTPM
hypothalamus: 9.2 nTPM
pons: 8.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.65
gnomAD pLI: 0.25
gnomAD missense Z: 0.72
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

signaling receptor binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CD58 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD58 as an antibody target. Whether an autoantibody or antibody against CD58 could matter depends on whether native CD58 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD58 is annotated at the cell surface, where native CD58 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CD58 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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