Seroatlas · Human Serome Atlas

STMN3

Stathmin-3

Also known as: SCLIP, STMN3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NZ72
Gene: STMN3
Ensembl: ENSG00000197457
Chromosome: 20
Canonical length: 180 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Cytosol

OverviewNCBI Gene

This gene encodes a protein which is a member of the stathmin protein family. Members of this protein family form a complex with tubulins at a ratio of 2 tubulins for each stathmin protein. Microtubules require the ordered assembly of alpha- and beta-tubulins, and formation of a complex with stathmin disrupts microtubule formation and function. A pseudogene of this gene is located on chromosome 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Canonical amino-acid sequenceUniProt

180 residues, UniProt reviewed canonical sequence.

>Q9NZ72|STMN3
     1  MASTISAYKE KMKELSVLSL ICSCFYTQPH PNTVYQYGDM EVKQLDKRAS GQSFEVILKS
    61  PSDLSPESPM LSSPPKKKDT SLEELQKRLE AAEERRKTQE AQVLKQLAER REHEREVLHK
   121  ALEENNNFSR QAEEKLNYKM ELSKEIREAH LAALRERLRE KELHAAEVRR NKEQREEMSG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STMN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 337 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 337 nTPM
amygdala: 285 nTPM
basal ganglia: 273 nTPM
hippocampal formation: 265 nTPM
cerebellum: 252 nTPM
hypothalamus: 246 nTPM

Single-cell type

other brain neurons: 120 nCPM
retinal amacrine cells: 96 nCPM
brain excitatory neurons: 91 nCPM
brain inhibitory neurons: 90 nCPM
granulosa cells: 76 nCPM
retinal bipolar cells: 72 nCPM

Immune cell

naive CD4 T-cell: 6.2 nTPM
naive CD8 T-cell: 5.3 nTPM
memory CD4 T-cell: 5.2 nTPM
memory CD8 T-cell: 4.5 nTPM
MAIT T-cell: 2.7 nTPM
gdT-cell: 2.5 nTPM

Brain region

pons: 545 nTPM
cerebral cortex: 523 nTPM
amygdala: 382 nTPM
basal ganglia: 382 nTPM
medulla oblongata: 378 nTPM
hippocampal formation: 362 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.91
gnomAD pLI: 0.08
gnomAD missense Z: 1.34
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STMN3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STMN3 as an antibody target. Whether an autoantibody or antibody against STMN3 could matter depends on whether native STMN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STMN3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STMN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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