Seroatlas · Human Serome Atlas

CENPX

Centromere protein X

Also known as: CENP-X, CENPX_HUMAN, FAAP10, MGC14480, MHF2, STRA13

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MT69
Gene: CENPX
Ensembl: ENSG00000169689
Chromosome: 17
Canonical length: 81 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables DNA binding activity. Contributes to double-stranded DNA binding activity. Involved in interstrand cross-link repair; replication fork processing; and resolution of meiotic recombination intermediates. Located in chromatin. Part of FANCM-MHF complex; Fanconi anaemia nuclear complex; and inner kinetochore. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

81 residues, UniProt reviewed canonical sequence.

>A8MT69|CENPX
     1  MEGAGAGSGF RKELVSRLLH LHFKDDKTKV SGDALQLMVE LLKVFVVEAA VRGVRQAQAE
    61  DALRVDVDQL EKVLPQLLLD F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CENPX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 91 nTPM

Expression across tissuesHPA

Tissue

liver: 91 nTPM
cerebellum: 73 nTPM
prostate: 66 nTPM
esophagus: 63 nTPM
cerebral cortex: 58 nTPM
amygdala: 57 nTPM

Single-cell type

extravillous trophoblasts: 638 nCPM
esophageal basal cells: 429 nCPM
colonocytes: 284 nCPM
enteric transient amplifying cells: 283 nCPM
esophageal suprabasal cells: 276 nCPM
goblet cells: 236 nCPM

Immune cell

classical monocyte: 113 nTPM
T-reg: 111 nTPM
memory B-cell: 107 nTPM
plasmacytoid DC: 106 nTPM
total PBMC: 100 nTPM
intermediate monocyte: 100 nTPM

Brain region

cerebellum: 35 nTPM
thalamus: 31 nTPM
white matter: 31 nTPM
pons: 29 nTPM
midbrain: 28 nTPM
medulla oblongata: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0.11
DepMap mean gene effect: -0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

DNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Centromere protein X
CENP-S associating Centromere protein X

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CENPX in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CENPS

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CENPX as an antibody target. Whether an autoantibody or antibody against CENPX could matter depends on whether native CENPX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CENPX is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CENPX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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