MRCK kinase PH domain

Definition

This entry represents a pleckstrin homology (PH) domain found in MRCK (myotonic dystrophy kinase-related Cdc42-binding kinase) proteins that forms part of a tripartite C1-PH-CNH regulatory module. The PH domain is distinguished by a loop insertion between strands beta6 and beta7 that packs against the CNH domain. The domain contains conserved basic residues in the beta1-beta2 loop that may be involved in membrane binding. This PH domain shows weak binding to phosphoinositides with a preference for di-phosphorylated PIPs. The domain architecture of MRCK proteins includes an N-terminal kinase domain, a coiled-coil region, and C-terminal C1, PH and CNH domains arranged in a tripartite module that helps localize the protein to membranes.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• CDC42BPA
• CDC42BPB
• CDC42BPG
• ROCK1
• ROCK2