MRCK/ROCK kinase, PH domain

Definition

This entry represents a pleckstrin homology (PH) domain found in Serine/threonine-protein kinase MRCK alpha/beta/gamma, in Rho-associated protein kinase 1/2 (ROCK1/2) and similar sequences mainly found in animals. MRCK (myotonic dystrophy kinase-related Cdc42-binding kinase) forms part of a tripartite C1-PH-CNH regulatory module. The PH domain is distinguished by a loop insertion between strands β6 and β7 that packs against the CNH domain. The domain contains conserved basic residues in the β1-β2 loop that may be involved in membrane binding. This PH domain shows weak binding to phosphoinositides with a preference for di-phosphorylated PIPs. The domain architecture of MRCK proteins includes an N-terminal kinase domain, a coiled-coil region, and C-terminal C1, PH and CNH domains arranged in a tripartite module that helps localise the protein to membranes. Human Serine/threonine-protein kinase MRCK alpha/gamma are important downstream effectors of CDC42 and play a role in the regulation of cytoskeleton reorganisation and cell migration [[cite:PMID:15723050], [cite:PMID:9092543], [cite:PMID:9418861]]. Rho-associated protein kinase 1/2 are key regulator of the actin cytoskeleton and cell polarity [[cite:PMID:10652353], [cite:PMID:11283607], [cite:PMID:17158456], [cite:PMID:18573880], [cite:PMID:19131646]].

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• CDC42BPA
• CDC42BPB
• CDC42BPG
• ROCK1
• ROCK2