Seroatlas · Human Serome Atlas

TRAT1

T-cell receptor-associated transmembrane adapter 1

Also known as: HSPC062, TCRIM, TRAT1_HUMAN, TRIM

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PIZ9
Gene: TRAT1
Ensembl: ENSG00000163519
Chromosome: 3
Canonical length: 186 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Plasma membrane,Mitotic spindle,Centriolar satellite
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable transmembrane receptor protein tyrosine kinase adaptor activity. Acts upstream of or within negative regulation of receptor recycling; negative regulation of transport; and positive regulation of signal transduction. Located in centriolar satellite; mitotic spindle; and plasma membrane. Part of T cell receptor complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

186 residues, UniProt reviewed canonical sequence.

>Q6PIZ9|TRAT1
     1  MSGISGCPFF LWGLLALLGL ALVISLIFNI SHYVEKQRQD KMYSYSSDHT RVDEYYIEDT
    61  PIYGNLDDMI SEPMDENCYE QMKARPEKSV NKMQEATPSA QATNETQMCY ASLDHSVKGK
   121  RRKPRKQNTH FSDKDGDEQL HAIDASVSKT TLVDSFSPES QAVEENIHDD PIRLFGLIRA
   181  KREPIN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRAT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 74 nTPM

Expression across tissuesHPA

Tissue

thymus: 74 nTPM
lymph node: 22 nTPM
tonsil: 12 nTPM
appendix: 10 nTPM
spleen: 8 nTPM
small intestine: 2.8 nTPM

Single-cell type

t-cells: 145 nCPM
thymocytes: 53 nCPM
nk-cells: 42 nCPM
innate lymphoid cells: 24 nCPM
cone photoreceptor cells: 19 nCPM
conjunctival goblet cells: 3.9 nCPM

Immune cell

basophil: 397 nTPM
naive CD4 T-cell: 314 nTPM
memory CD4 T-cell: 230 nTPM
total PBMC: 139 nTPM
memory CD8 T-cell: 120 nTPM
MAIT T-cell: 117 nTPM

Brain region

cerebral cortex: 0.2 nTPM
basal ganglia: 0.1 nTPM
choroid plexus: 0.1 nTPM
medulla oblongata: 0.1 nTPM
pons: 0.1 nTPM
spinal cord: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0.06
gnomAD missense Z: -0.36
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

transmembrane receptor protein tyrosine kinase adaptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

SHP2-interacting transmembrane adaptor protein, SIT
T-cell receptor-associated transmembrane adapter 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRAT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRAT1 as an antibody target. Whether an autoantibody or antibody against TRAT1 could matter depends on whether native TRAT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRAT1 is annotated at the cell surface, where native TRAT1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TRAT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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