Seroatlas · Human Serome Atlas

LY6E

Lymphocyte antigen 6E

Also known as: LY6E_HUMAN, RIG-E, SCA-2, TSA-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q16553
Gene: LY6E
Ensembl: ENSG00000160932
Chromosome: 8
Canonical length: 131 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

This gene belongs to the human Ly6 gene family and encodes a glycosylphosphatidyl-inositol (GPI)-anchored cell surface protein. The protein plays an important role in T cell physiology, oncogenesis and immunological regulation. The protein is also involved in modulation of viral infection by coronaviruses, SARS-CoV, MERS-CoV and SARS-CoV-2. [provided by RefSeq, Aug 2021]

Canonical amino-acid sequenceUniProt

131 residues, UniProt reviewed canonical sequence.

>Q16553|LY6E
     1  MKIFLPVLLA ALLGVERASS LMCFSCLNQK SNLYCLKPTI CSDQDNYCVT VSASAGIGNL
    61  VTFGHSLSKT CSPACPIPEG VNVGVASMGI SCCQSFLCNF SAADGGLRAS VTLLGAGLLL
   121  SLLPALLRFG P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LY6E can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 616 nTPM

Expression across tissuesHPA

Tissue

liver: 616 nTPM
adrenal gland: 251 nTPM
hippocampal formation: 245 nTPM
lung: 229 nTPM
adipose tissue: 216 nTPM
spleen: 212 nTPM

Single-cell type

brain excitatory neurons: 46 nCPM
other brain neurons: 36 nCPM
brain inhibitory neurons: 26 nCPM
extravillous trophoblasts: 23 nCPM
papillary tip epithelial cells: 21 nCPM
podocytes: 18 nCPM

Immune cell

non-classical monocyte: 757 nTPM
intermediate monocyte: 567 nTPM
NK-cell: 274 nTPM
total PBMC: 242 nTPM
gdT-cell: 187 nTPM
naive B-cell: 161 nTPM

Brain region

hippocampal formation: 95 nTPM
cerebral cortex: 74 nTPM
spinal cord: 67 nTPM
medulla oblongata: 62 nTPM
thalamus: 53 nTPM
amygdala: 50 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0.32
gnomAD missense Z: 0.57
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LY6E in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LY6E as an antibody target. Whether an autoantibody or antibody against LY6E could matter depends on whether native LY6E is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LY6E is annotated at the cell surface, where native LY6E is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LY6E as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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