Seroatlas · Human Serome Atlas

F11R

Junctional adhesion molecule A

Also known as: CD321, JAM-1, JAM-A, JAM1, JAM1_HUMAN, JAMA, JCAM, PAM-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y624
Gene
F11R
Ensembl
ENSG00000158769
Chromosome
1
Canonical length
299 aa
Protein class
CD markers, Plasma proteins, Predicted membrane proteins
Subcellular location
Cell Junctions,Microtubules
Quaternary structure
Homodimer

OverviewNCBI Gene

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

299 residues, UniProt reviewed canonical sequence.

>Q9Y624|F11R
     1  MGTKAQVERK LLCLFILAIL LCSLALGSVT VHSSEPEVRI PENNPVKLSC AYSGFSSPRV
    61  EWKFDQGDTT RLVCYNNKIT ASYEDRVTFL PTGITFKSVT REDTGTYTCM VSEEGGNSYG
   121  EVKVKLIVLV PPSKPTVNIP SSATIGNRAV LTCSEQDGSP PSEYTWFKDG IVMPTNPKST
   181  RAFSNSSYVL NPTTGELVFD PLSASDTGEY SCEARNGYGT PMTSNAVRME AVERNVGVIV
   241  AAVLVTLILL GILVFGIWFA YSRGHFDRTK KGTSSKKVIY SQPSARSEGE FKQTSSFLV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against F11R can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
88 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 88 nTPM
  • liver: 69 nTPM
  • lung: 67 nTPM
  • small intestine: 60 nTPM
  • duodenum: 53 nTPM
  • salivary gland: 50 nTPM

Single-cell type

  • esophageal apical cells: 314 nCPM
  • extravillous trophoblasts: 255 nCPM
  • ocular epithelial cells: 242 nCPM
  • urothelial cells: 235 nCPM
  • pancreatic acinar cells: 174 nCPM
  • alveolar cells type 1: 165 nCPM

Immune cell

  • eosinophil: 166 nTPM
  • neutrophil: 114 nTPM
  • basophil: 35 nTPM
  • classical monocyte: 31 nTPM
  • total PBMC: 25 nTPM
  • myeloid DC: 25 nTPM

Brain region

  • choroid plexus: 14 nTPM
  • thalamus: 12 nTPM
  • medulla oblongata: 11 nTPM
  • midbrain: 9.8 nTPM
  • pons: 9.8 nTPM
  • cerebral cortex: 9.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.01
gnomAD pLI
0
gnomAD missense Z
0.95
DepMap mean gene effect
-0.17
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of F11R in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads F11R as an antibody target. Whether an autoantibody or antibody against F11R could matter depends on whether native F11R is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

F11R is annotated at the cell surface, where native F11R is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label F11R as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/F11R. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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