Seroatlas · Human Serome Atlas

GRAMD1C

Protein Aster-C

Also known as: ASTRC_HUMAN, DKFZp434C0328

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IYS0
Gene
GRAMD1C
Ensembl
ENSG00000178075
Chromosome
3
Canonical length
662 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to enable cholesterol binding activity and cholesterol transfer activity. Predicted to be involved in cellular response to cholesterol and intracellular sterol transport. Predicted to be located in endoplasmic reticulum; membrane; and organelle membrane contact site. Predicted to be active in endoplasmic reticulum membrane; endoplasmic reticulum-plasma membrane contact site; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

662 residues, UniProt reviewed canonical sequence.

>Q8IYS0|GRAMD1C
     1  MEGAPTVRQV MNEGDSSLAT DLQEDVEENP SPTVEENNVV VKKQGPNLHN WSGDWSFWIS
    61  SSTYKDRNEE YRRQFTHLPD TERLIADYAC ALQRDILLQG RLYLSENWLC FYSNIFRWET
   121  TISIALKNIT FMTKEKTARL IPNAIQIVTE SEKFFFTSFG ARDRSYLSIF RLWQNVLLDK
   181  SLTRQEFWQL LQQNYGTELG LNAEEMENLS LSIEDVQPRS PGRSSLDDSG ERDEKLSKSI
   241  SFTSESISRV SETESFDGNS SKGGLGKEES QNEKQTKKSL LPTLEKKLTR VPSKSLDLNK
   301  NEYLSLDKSS TSDSVDEENV PEKDLHGRLF INRIFHISAD RMFELLFTSS RFMQKFASSR
   361  NIIDVVSTPW TAELGGDQLR TMTYTIVLNS PLTGKCTAAT EKQTLYKESR EARFYLVDSE
   421  VLTHDVPYHD YFYTVNRYCI IRSSKQKCRL RVSTDLKYRK QPWGLVKSLI EKNSWSSLED
   481  YFKQLESDLL IEESVLNQAI EDPGKLTGLR RRRRTFNRTA ETVPKLSSQH SSGDVGLGAK
   541  GDITGKKKEM ENYNVTLIVV MSIFVLLLVL LNVTLFLKLS KIEHAAQSFY RLRLQEEKSL
   601  NLASDMVSRA ETIQKNKDQA HRLKGVLRDS IVMLEQLKSS LIMLQKTFDL LNKNKTGMAV
   661  ES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GRAMD1C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • liver: 26 nTPM
  • kidney: 22 nTPM
  • small intestine: 16 nTPM
  • testis: 16 nTPM
  • retina: 13 nTPM
  • pancreas: 12 nTPM

Single-cell type

  • astrocytes: 323 nCPM
  • endometrial glandular cells: 267 nCPM
  • pituitary stem cells: 183 nCPM
  • late spermatids: 154 nCPM
  • late primary spermatocytes: 144 nCPM
  • cone photoreceptor cells: 135 nCPM

Immune cell

  • naive B-cell: 3 nTPM
  • memory B-cell: 2.7 nTPM
  • neutrophil: 2.1 nTPM
  • memory CD8 T-cell: 0.2 nTPM
  • gdT-cell: 0.1 nTPM
  • memory CD4 T-cell: 0.1 nTPM

Brain region

  • midbrain: 22 nTPM
  • thalamus: 20 nTPM
  • medulla oblongata: 19 nTPM
  • cerebral cortex: 17 nTPM
  • amygdala: 17 nTPM
  • spinal cord: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.08
gnomAD pLI
0
gnomAD missense Z
0.84
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GRAMD1C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GRAMD1C as an antibody target. Whether an autoantibody or antibody against GRAMD1C could matter depends on whether native GRAMD1C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GRAMD1C is annotated at the cell surface, where native GRAMD1C is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GRAMD1C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GRAMD1C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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