Seroatlas · Human Serome Atlas

CCL3

C-C motif chemokine 3

Also known as: CCL3_HUMAN, G0S19-1, LD78ALPHA, MIP-1-alpha, SCYA3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P10147
Gene
CCL3
Ensembl
ENSG00000277632
Chromosome
17
Canonical length
92 aa
Protein class
Cancer-related genes, Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus type 1.[provided by RefSeq, Sep 2010]

Canonical amino-acid sequenceUniProt

92 residues, UniProt reviewed canonical sequence.

>P10147|CCL3
     1  MQVSTAALAV LLCTMALCNQ FSASLAADTP TACCFSYTSR QIPQNFIADY FETSSQCSKP
    61  GVIFLTKRSR QVCADPSEEW VQKYVSDLEL SA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
73 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 73 nTPM
  • spleen: 49 nTPM
  • lung: 35 nTPM
  • adipose tissue: 17 nTPM
  • cerebral cortex: 16 nTPM
  • adrenal gland: 15 nTPM

Single-cell type

  • hofbauer cells: 94 nCPM
  • nk-cells: 63 nCPM
  • macrophages: 48 nCPM
  • kupffer cells: 45 nCPM
  • microglia: 35 nCPM
  • monocytes: 31 nCPM

Immune cell

  • gdT-cell: 24 nTPM
  • total PBMC: 12 nTPM
  • eosinophil: 11 nTPM
  • neutrophil: 11 nTPM
  • naive B-cell: 10 nTPM
  • naive CD8 T-cell: 6.8 nTPM

Brain region

  • cerebral cortex: 2.7 nTPM
  • white matter: 2.7 nTPM
  • basal ganglia: 1.5 nTPM
  • medulla oblongata: 1.4 nTPM
  • thalamus: 1 nTPM
  • amygdala: 0 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CCL3.

Disease | ImmuneIEDB

Conditions an epitope on CCL3 was assayed in.

ReferencesPubMed · IEDB

Publications for CCL3 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

2 publications

Reference: T cellIEDB

2 publications

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.04
gnomAD pLI
0.35
gnomAD missense Z
0.12
DepMap mean gene effect
-0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCL3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCL3 as an antibody target. Whether an autoantibody or antibody against CCL3 could matter depends on whether native CCL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCL3 is annotated as secreted, so native CCL3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CCL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCL3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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