Seroatlas · Human Serome Atlas

CCL5

C-C motif chemokine 5

Also known as: CCL5_HUMAN, D17S136E, MGC17164, RANTES, SCYA5, SISd, TCP228

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P13501
Gene
CCL5
Ensembl
ENSG00000271503
Chromosome
17
Canonical length
91 aa
Protein class
Cancer-related genes, Human disease related genes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

91 residues, UniProt reviewed canonical sequence.

>P13501|CCL5
     1  MKVSAAALAV ILIATALCAP ASASPYSSDT TPCCFAYIAR PLPRAHIKEY FYTSGKCSNP
    61  AVVFVTRKNR QVCANPEKKW VREYINSLEM S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCL5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
127 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 127 nTPM
  • spleen: 121 nTPM
  • bone marrow: 115 nTPM
  • small intestine: 79 nTPM
  • lung: 54 nTPM
  • duodenum: 46 nTPM

Single-cell type

  • nk-cells: 175 nCPM
  • t-cells: 127 nCPM
  • platelets: 118 nCPM
  • innate lymphoid cells: 9.5 nCPM
  • pdcs: 6.4 nCPM
  • parietal cells: 3.5 nCPM

Immune cell

  • memory CD8 T-cell: 7,136 nTPM
  • gdT-cell: 6,781 nTPM
  • total PBMC: 6,634 nTPM
  • MAIT T-cell: 4,212 nTPM
  • naive CD8 T-cell: 4,027 nTPM
  • NK-cell: 2,043 nTPM

Brain region

  • medulla oblongata: 14 nTPM
  • pons: 12 nTPM
  • white matter: 11 nTPM
  • spinal cord: 11 nTPM
  • choroid plexus: 9.6 nTPM
  • cerebral cortex: 8.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CCL5.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 16 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Human immunodeficiency virus type 1, rapid disease progression with infection by

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.82
gnomAD pLI
0
gnomAD missense Z
0.4
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCL5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCL5 as an antibody target. Whether an autoantibody or antibody against CCL5 could matter depends on whether native CCL5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCL5 is annotated as secreted, so native CCL5 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CCL5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCL5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...