Seroatlas · Human Serome Atlas

CCL23

C-C motif chemokine 23

Also known as: CCL23_HUMAN, Ckb-8, CKb8, MIP-3, MPIF-1, SCYA23

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P55773
Gene
CCL23
Ensembl
ENSG00000274736
Chromosome
17
Canonical length
120 aa
Protein class
Cancer-related genes, Plasma proteins, Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. In addition, the product of this gene is a potent agonist of the chemokine (C-C motif) receptor 1. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

120 residues, UniProt reviewed canonical sequence.

>P55773|CCL23
     1  MKVSVAALSC LMLVTALGSQ ARVTKDAETE FMMSKLPLEN PVLLDRFHAT SADCCISYTP
    61  RSIPCSLLES YFETNSECSK PGVIFLTKKG RRFCANPSDK QVQVCMRMLK LDTRIKTRKN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCL23 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • lung: 20 nTPM
  • cervix: 15 nTPM
  • spleen: 14 nTPM
  • endometrium: 13 nTPM
  • kidney: 11 nTPM
  • smooth muscle: 10 nTPM

Single-cell type

  • vascular endothelial cells: 69 nCPM
  • kupffer cells: 15 nCPM
  • hepatic stellate cells: 13 nCPM
  • mast cells: 13 nCPM
  • megakaryocytes: 6.2 nCPM
  • lymphatic endothelial cells: 5.3 nCPM

Immune cell

  • eosinophil: 184 nTPM
  • memory B-cell: 1.1 nTPM
  • non-classical monocyte: 1.1 nTPM
  • basophil: 1 nTPM
  • classical monocyte: 0.7 nTPM
  • intermediate monocyte: 0.7 nTPM

Brain region

  • cerebral cortex: 0.3 nTPM
  • choroid plexus: 0.2 nTPM
  • thalamus: 0.2 nTPM
  • medulla oblongata: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.72
gnomAD pLI
0
gnomAD missense Z
0.26
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCL23 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCL23 as an antibody target. Whether an autoantibody or antibody against CCL23 could matter depends on whether native CCL23 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCL23 is annotated as secreted, so native CCL23 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CCL23 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCL23. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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