Seroatlas · Human Serome Atlas

LRRC45

Leucine-rich repeat-containing protein 45

Also known as: LRC45_HUMAN, MGC20806

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96CN5
Gene: LRRC45
Ensembl: ENSG00000169683
Chromosome: 17
Canonical length: 670 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Centrosome,Basal body,Cytosol,Mid piece,Principal piece

OverviewNCBI Gene

Located in cytosol; microtubule organizing center; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

670 residues, UniProt reviewed canonical sequence.

>Q96CN5|LRRC45
     1  MEEFRRSYSR LCRESGAEPQ EAVLQQLHQL PRGRLDLATQ SLTVETCRAL GKLLPRETLC
    61  TELVLSDCML SEEGATLLLR GLCANTVLRF LDLKGNNLRA AGAEALGKLL QQNKSIQSLT
   121  LEWNSLGTWD DAFATFCGGL AANGALQRLD LRNNQISHKG AEELALALKG NTTLQQLDLR
   181  WNNVGLLGGR ALMNCLPSNR TLWRLDLAGN NIPGDVLRAV EQAMGHSQDR LTTFQENQAR
   241  THVLSKEVQH LREEKSKQFL DLMETIDKQR EEMAKSSRAS AARVGQLQEA LNERHSIINA
   301  LKAKLQMTEA ALALSEQKAQ DLGELLATAE QEQLSLSQRQ AKELKLEQQE AAERESKLLR
   361  DLSAANEKNL LLQNQVDELE RKFRCQQEQL FQTRQEMTSM SAELKMRAIQ AEERLDMEKR
   421  RCRQSLEDSE SLRIKEVEHM TRHLEESEKA MQERVQRLEA ARLSLEEELS RVKAAALSER
   481  GQAEEELIKA KSQARLEEQQ RLAHLEDKLR LLAQARDEAQ GACLQQKQVV AEAQTRVSQL
   541  GLQVEGLRRR LEELQQELSL KDQERVAEVS RVRVELQEQN GRLQAELAAQ EALREKAAAL
   601  ERQLKVMASD HREALLDRES ENASLREKLR LREAEIARIR DEEAQRASFL QNAVLAYVQA
   661  SPVRTLSPPK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC45 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 23 nTPM
liver: 18 nTPM
stomach: 10 nTPM
esophagus: 10 nTPM
pancreas: 9.7 nTPM
salivary gland: 9.3 nTPM

Single-cell type

respiratory ciliated cells: 66 nCPM
fallopian tube ciliated cells: 49 nCPM
extravillous trophoblasts: 41 nCPM
tuft cells: 23 nCPM
epididymal principal cells: 23 nCPM
enteric transient amplifying cells: 23 nCPM

Immune cell

basophil: 2.3 nTPM
memory CD4 T-cell: 1.6 nTPM
memory CD8 T-cell: 1.6 nTPM
eosinophil: 1.5 nTPM
gdT-cell: 1.4 nTPM
MAIT T-cell: 1.4 nTPM

Brain region

cerebellum: 19 nTPM
cerebral cortex: 9.6 nTPM
pons: 9.2 nTPM
medulla oblongata: 8.9 nTPM
midbrain: 8.9 nTPM
hippocampal formation: 8.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LRRC45.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 192 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

LRRC45 associated neurological ciliopathy

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.88
gnomAD pLI: 0
gnomAD missense Z: 1.02
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LRRC45 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC45 as an antibody target. Whether an autoantibody or antibody against LRRC45 could matter depends on whether native LRRC45 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC45 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC45 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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