Seroatlas · Human Serome Atlas

CATSPERB

Cation channel sperm-associated auxiliary subunit beta

Also known as: C14orf161, CTSRB_HUMAN, FLJ14298

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H7T0
Gene: CATSPERB
Ensembl: ENSG00000133962
Chromosome: 14
Canonical length: 1116 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Mid piece

OverviewNCBI Gene

Predicted to be involved in cell differentiation and spermatogenesis. Predicted to be located in sperm principal piece. Predicted to be part of CatSper complex. Predicted to be active in cilium. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1116 residues, UniProt reviewed canonical sequence.

>Q9H7T0|CATSPERB
     1  MESPLIYVSV LLLNIFEFSS GIVYNKDDTE KRFACSNKGF PQENEIIKLY LFLENLKIQC
    61  FFQTENEIAS KAMLSVFTSG GLAPSLGIMN STYNGIFHFN LTLFSDRILW LVDIPRENIT
   121  QSTDIAAVEE WLVRITLHHG LNIYATEGTL LDVIREPILQ WTPGDVIPES EISKLYPHVV
   181  DLKVTKCPCA NDVALLGFIV DTIVDGVYIG ITFGGFWHDY DTTWFNMTQT IYSQLQEEYE
   241  DLSLVDMVLT NHFLVILTSL GLFVSEDLRY PSRHSLSFSR ADFCGFERVD YVKGKLWYNE
   301  RCFANREHFE VDYVTVTFER NRTLSESSSC FYSQEPFLEW VPCLPHIFKG IKIFPTVLTF
   361  LVDQERGTGV YLFYNKVRKT AIASVSTLRN NEPNSQSKFP IFRFPSSFSS PVGMVFHPRS
   421  HFLYAYGNQI WLSVDGGNTF QLIANFHDDI IKKTFHSFYT SAITFVSQRG KVYSTKAGMG
   481  RYSAVGSVTE RIFTLYYDHL GFLHKLTLGR FEASGPPTAF GNSRNLFGQP PDMGFETALA
   541  PQHTSLDEII FFAYVPENEP QETIYSKKFG NIHYGKVIHS GKTGRAYIRK VLQHTTPKGF
   601  LSSVIAEMKE PFGLEEVNES SCLSSSLLIN KAGNVYKLTL DSQVVQALFE DTDIEKTVVL
   661  PGYSSFLITS ILDNKNALAI ATMPESAPNN MTFLKSTWFL YNFGQRNGRT WKIYSKPCNY
   721  WFQHDDSPSL NIVKYIDLGN SYVLKAKVIR NAKGFRMLEI PLLTVFVGNP NLLEVTAEVT
   781  FDDTDSYVIT ISAASKVLHQ GSTSLAFIMW SASTECFVTT MVPTLKSSCS YLRSMHHIPS
   841  KFIPFEDWIS GVHKDSQGFN LIKTLPINYR PPSNMGIAIP LTDNFYHADP SKPIPRNMFH
   901  MSKKTGKFKQ CANVSTREEC NCTKDQKFSH AVAFSDCREK VPRFKFPITQ YPVSLEIINE
   961  DGRVPLQSPY LVTVTEVNMR HNWKLKHTVP ENIKRMKQLV EPILGAAVYN PSGLNLSIKG
  1021  SELFHFRVTV ISGVTFCNLI EEFQIYVDEA PLPFPGHTLI AVATAVVLGG LIFIAFMFQL
  1081  QGIHPWRTFQ RWIRRNQEKF SSISLSELIH RSKSEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CATSPERB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

pancreas: 10 nTPM
salivary gland: 2.4 nTPM
skin: 2.1 nTPM
blood vessel: 1.9 nTPM
stomach: 1.4 nTPM
skeletal muscle: 1.1 nTPM

Single-cell type

papillary tip epithelial cells: 103 nCPM
renal collecting duct principal cells: 88 nCPM
renal connecting tubule cells: 32 nCPM
loop of henle epithelial cells: 30 nCPM
renal collecting duct intercalated cells: 27 nCPM
early spermatids: 20 nCPM

Immune cell

basophil: 0.3 nTPM
MAIT T-cell: 0.2 nTPM
memory CD4 T-cell: 0.2 nTPM
naive CD8 T-cell: 0.2 nTPM
gdT-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM

Brain region

cerebellum: 4.9 nTPM
white matter: 4.5 nTPM
cerebral cortex: 3.9 nTPM
amygdala: 3.7 nTPM
basal ganglia: 3.7 nTPM
hippocampal formation: 3.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CATSPERB.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 146 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Male infertility

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0
gnomAD missense Z: 1.34
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Cation channel sperm-associated auxiliary subunit beta
Cation channel sperm-associated auxiliary subunit beta, N-terminal domain
Cation channel sperm-associated auxiliary subunit beta, 2nd domain
Cation channel sperm-associated protein subunit beta, C-terminal domain
CATSPERB, head domain
CATSPERB, Ig-like domain
CATSPERB, C-terminal domain
CATSPER protein subunit beta protein 1st domain
CATSPER subunit beta protein 2nd domain
CATSPERB head domain
CATSPERB Ig-like domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CATSPERB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CATSPERB as an antibody target. Whether an autoantibody or antibody against CATSPERB could matter depends on whether native CATSPERB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CATSPERB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CATSPERB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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