Seroatlas · Human Serome Atlas

EFCAB9

EF-hand calcium-binding domain-containing protein 9

Also known as: EFCB9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MZ26
Gene: EFCAB9
Ensembl: ENSG00000214360
Chromosome: 5
Canonical length: 197 aa
Protein class: Predicted intracellular proteins, Transporters

OverviewNCBI Gene

This gene encodes a protein with a C-terminal EF-hand calcium-binding domain similar to that found in penta-EF-hand (PEF) protein family members. The EF-hand is a helix-loop-helix structure with a canonical twelve-residue sequence that coordinates a calcium molecule with pentagonal bipyramidal symmetry. [provided by RefSeq, Jul 2017]

Canonical amino-acid sequenceUniProt

197 residues, UniProt reviewed canonical sequence.

>A8MZ26|EFCAB9
     1  MRLKQGSFLW YLYLDKIYCL LSVRNVKALA EYFHILDVHG KNTLNDVLFY HFLHHVTDLK
    61  KAQINIVFDM LDWNAVGEID FEKFYMLVCM LLAHQNHLEG QFMYRHSRPV FDLLDLKGDL
   121  RIGAKNFEMY RFLFNIQKQE LKDLFRDFDI TGDNRLNYQE FKLYTIIYTD KLQKRQKTEE
   181  KEKGERKRSL YSKCHIK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EFCAB9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 9.5 nTPM

Expression across tissuesHPA

Tissue

testis: 9.5 nTPM
cerebellum: 0.2 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

early spermatids: 93 nCPM
late primary spermatocytes: 83 nCPM
late spermatids: 35 nCPM
endometrial secretory cells: 7.8 nCPM
epicardial cells: 6.8 nCPM
paneth cells: 3.9 nCPM

Immune cell

myeloid DC: 0.3 nTPM
intermediate monocyte: 0.1 nTPM
non-classical monocyte: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

cerebellum: 3.9 nTPM
pons: 0.3 nTPM
basal ganglia: 0.2 nTPM
cerebral cortex: 0.2 nTPM
hippocampal formation: 0.2 nTPM
white matter: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.76
gnomAD pLI: 0
gnomAD missense Z: 1.02
DepMap mean gene effect: 0.12
DepMap dependency class: none

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

EF-hand domain
EF-hand domain pair
EF-hand domain pair
EF-hand calcium-binding domain-containing protein 9

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EFCAB9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EFCAB9 as an antibody target. Whether an autoantibody or antibody against EFCAB9 could matter depends on whether native EFCAB9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EFCAB9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EFCAB9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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