Seroatlas · Human Serome Atlas

CATSPERG

Cation channel sperm-associated auxiliary subunit gamma

Also known as: C19orf15, CTSRG_HUMAN, DKFZp434A1022, FLJ46353

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZRH7
Gene: CATSPERG
Ensembl: ENSG00000099338
Chromosome: 19
Canonical length: 1159 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters
Subcellular location: Mid piece,Principal piece
Secretome location: Secreted in male reproductive system

OverviewNCBI Gene

CATSPERG is a subunit of the CATSPER (see CATSPER1; MIM 606389) sperm calcium channel, which is required for sperm hyperactivated motility and male fertility (Wang et al., 2009 [PubMed 19516020]).[supplied by OMIM, Jul 2010]

Canonical amino-acid sequenceUniProt

1159 residues, UniProt reviewed canonical sequence.

>Q6ZRH7|CATSPERG
     1  MCGPAMFPAG PPWPRVRVVQ VLWALLAVLL ASWRLWAIKD FQECTWQVVL NEFKRVGESG
    61  VSDSFFEQEP VDTVSSLFHM LVDSPIDPSE KYLGFPYYLK INYSCEEKPS EDLVRMGHLT
   121  GLKPLVLVTF QSPVNFYRWK IEQLQIQMEA APFRSKEPCM AEEVCSMSWY TPMPIKKGSV
   181  VMRVDISSNG LGTFIPDKRF QMNINGFLKR DRDNNIQFTV GEELFNLMPQ YFVGVSSRPL
   241  WHTVDQSPVL ILGGIPNEKY VLMTDTSFKD FSLVELSIDS CWVGSFYCPH SGFTATIYDT
   301  IATESTLFIR QNQLVYYFTG TYTTLYERNR GSGSWIRVLA SECIKKLCPV YFHSNGSEYI
   361  MALTTGKHEG YVHFGTIRDG QVSFEMLPRQ WSVCEQIGVT TCSIIWSEYI AGEYTLLLLV
   421  ESGYGNASKR FQVVSYNTAS DDLELLYHIP EFIPEARGLE FLMILGTESY TSTAMAPKGI
   481  FCNPYNNLIF IWGNFLLQSS NKENFIYLAD FPKELSIKYM ARSFRGAVAI VTETEEIWYL
   541  LEGSYRVYQL FPSKGWQVHI SLKLMQQSSL YASNETMLTL FYEDSKLYQL VYLMNNQKGQ
   601  LVKRLVPVEQ LLMYQQHTSH YDLERKGGYL MLSFIDFCPF SVMRLRSLPS PQRYTRQERY
   661  RARPPRVLER SGFHNENSLA IYQGLVYYLL WLHSVYDKPY ADPVHDPTWR WWANNKQDQD
   721  YYFFLASNWR SAGGVSIEMD SYEKIYNLES AYELPERIFL DKGTEYSFAI FLSAQGHSFR
   781  TQSELGTAFQ LHSQVDVGVV LADPGCIEAS VKQEVLINRN SVLFSITLKD KKLCYDQGIS
   841  GHHLMETSMT VNVVGSSGLC FQETHLGPHM QGNLMVPVFI GCPPGKRLAF DITYTLEYSR
   901  LKNKHYFDCV NVNPEMPCFL FRDIFYPFFL IQDLVTGDSG SFQGSYVLLV VGGGPTLDSL
   961  KDYSEDEIYR FNSPLDKTNS LIWTTRTTRT TKDSAFHIMS HESPGIEWLC LENAPCYDNV
  1021  PQGIFAPEFF FKVLVSNRGV DTSTYCNYQL TFLLHIHGLP LSPKRALFII MVSASVFVGL
  1081  VIFYIAFCLL WPLVVKGCTM IRWKINNLIA SESYYTYASI SGISSMPSLR HSRMGSMFSS
  1141  RMTEDRAEPK EAVERQLMT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CATSPERG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

testis: 31 nTPM
cerebellum: 2.3 nTPM
midbrain: 1.3 nTPM
skin: 0.9 nTPM
epididymis: 0.7 nTPM
spinal cord: 0.6 nTPM

Single-cell type

late spermatids: 96 nCPM
early primary spermatocytes: 73 nCPM
enterocytes: 68 nCPM
late primary spermatocytes: 65 nCPM
epididymal basal cells: 53 nCPM
early spermatids: 52 nCPM

Immune cell

neutrophil: 1.5 nTPM
non-classical monocyte: 0.7 nTPM
eosinophil: 0.6 nTPM
intermediate monocyte: 0.3 nTPM
classical monocyte: 0.2 nTPM
myeloid DC: 0.2 nTPM

Brain region

midbrain: 6.8 nTPM
white matter: 2.5 nTPM
cerebellum: 2.1 nTPM
cerebral cortex: 1.9 nTPM
pons: 1.9 nTPM
thalamus: 1.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CATSPERG.

Disease | ImmuneIEDB

Conditions an epitope on CATSPERG was assayed in.

intrahepatic cholangiocarcinoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.86
gnomAD pLI: 0
gnomAD missense Z: 1.38
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Cation channel sperm-associated auxiliary subunit gamma
CATSPERG, beta-propeller domain
CATSPERG, N-terminal domain
CATSPERG, C-terminal domain
CATSPERG, Ig-like domain
CATSPERG beta-propeller domain
CATSPERG N-terminal domain
CATSPERG C-terminal domain
CATSPERG Ig-like domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CATSPERG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CATSPERB

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CATSPERG as an antibody target. Whether an autoantibody or antibody against CATSPERG could matter depends on whether native CATSPERG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CATSPERG is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CATSPERG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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