Seroatlas · Human Serome Atlas

CATSPERE

Cation channel sperm-associated auxiliary subunit epsilon

Also known as: C1orf101, CTSRE_HUMAN, MGC33370

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5SY80
Gene
CATSPERE
Ensembl
ENSG00000179397
Chromosome
1
Canonical length
951 aa
Protein class
Predicted membrane proteins, Transporters
Subcellular location
Mid piece,Principal piece,End piece,Annulus

OverviewNCBI Gene

Predicted to be involved in flagellated sperm motility and sperm capacitation. Located in sperm principal piece. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

951 residues, UniProt reviewed canonical sequence.

>Q5SY80|CATSPERE
     1  MSAREVAVLL LWLSCYGSAL WRYSTNSPNY RIFSTRSTIK LEYEGTLFTE WSVPETCFVL
    61  NKSSPTTELR CSSPGVHAIK PIVTGPDEEE RYLFVESSHT CFLWYYRVRH FFNNFTQLIT
   121  VWAYDPESAD PDELLGNAEE PSINSIVLST QMATLGQKPV IHTVLKRKVY SSNEKMRRGT
   181  WRIVVPMTKD DALKEIRGNQ VTFQDCFIAD FLILLTFPLL TIPEIPGYLP ISSPRGSQLM
   241  ASWDACVVAS AVLVTDMETF HTTDSFKSWT RIRVPPDILS DDERRSVAHV ILSRDGIVFL
   301  INGVLYIKSF RGFIRLGGIV NLPDGGITGI SSRKWCWVNY LLKAKGRRST FAVWTENEIY
   361  LGSILLKFAR LVTTTELKNI LSLSVTATLT IDRVEYTGHP LEIAVFLNYC TVCNVTKKIF
   421  LVIYNEDTKQ WVSQDFTLDA PIDSVTMPHF TFSALPGLLL WNKHSIYYCY HNFTFTGILQ
   481  TPAGHGNLSM LSNDSIIHEV FIDYYGDILV KMENNVIFYS KINTRDAVKL HLWTNYTTRA
   541  FIFLSTSGQT YFLYALDDGT IQIQDYPLHL EAQSIAFTTK DKCPYMAFHN NVAHVFYFLD
   601  KGEALTVWTQ IVYPENTGLY VIVESYGPKI LQESHEISFE AAFGYCTKTL TLTFYQNVDY
   661  ERISDYFETQ DKHTGLVLVQ FRPSEYSKAC PIAQKVFQIA VGCDDKKFIA IKGFSKKGCH
   721  HHDFSYVIEK SYLRHQPSKN LRVRYIWGEY GCPLRLDFTE KFQPVVQLFD DNGYVKDVEA
   781  NFIVWEIHGR DDYSFNNTMA QSGCLHEAQT WKSMIELNKH LPLEEVWGPE NYKHCFSYAI
   841  GKPGDLNQPY EIINSSNGNH IFWPMGHSGM YVFRVKILDP NYSFCNLTAM FAIETFGLIP
   901  SPSVYLVASF LFVLMLLFFT ILVLSYFRYM RIYRRYIYEP LHKPQRKRKK N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CATSPERE can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • testis: 20 nTPM
  • epididymis: 2.5 nTPM
  • fallopian tube: 1.2 nTPM
  • pituitary gland: 1 nTPM
  • thyroid gland: 0.9 nTPM
  • parathyroid gland: 0.8 nTPM

Single-cell type

  • late primary spermatocytes: 121 nCPM
  • neutrophil progenitors: 119 nCPM
  • ependymal cells: 82 nCPM
  • respiratory ciliated cells: 76 nCPM
  • sertoli cells: 72 nCPM
  • pituitary stem cells: 68 nCPM

Immune cell

  • basophil: 0.3 nTPM
  • plasmacytoid DC: 0.2 nTPM
  • gdT-cell: 0.1 nTPM
  • memory B-cell: 0.1 nTPM
  • naive CD4 T-cell: 0.1 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • white matter: 3.3 nTPM
  • spinal cord: 3.1 nTPM
  • medulla oblongata: 2.8 nTPM
  • thalamus: 2.8 nTPM
  • pons: 2.7 nTPM
  • basal ganglia: 2.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.77
gnomAD pLI
0
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CATSPERE in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CATSPERE as an antibody target. Whether an autoantibody or antibody against CATSPERE could matter depends on whether native CATSPERE is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CATSPERE is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CATSPERE as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CATSPERE. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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