CATSPERZ
Cation channel sperm-associated auxiliary subunit zeta
Also known as: C11orf20, CTSRZ_HUMAN, DKFZP566E164, TEX40
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NTU4
- Gene
- CATSPERZ
- Ensembl
- ENSG00000219435
- Chromosome
- 11
- Canonical length
- 200 aa
- Protein class
- Predicted intracellular proteins, Transporters
- Subcellular location
- Primary cilium tip,Cytosol,Mid piece,Principal piece
OverviewNCBI Gene
Predicted to be involved in flagellated sperm motility; male meiotic nuclear division; and sperm capacitation. Located in cytoplasm and sperm principal piece. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
200 residues, UniProt reviewed canonical sequence.
>Q9NTU4|CATSPERZ
1 MEEKPSKVSL KSSDRQGSDE ESVHSDTRDL WTTTTLSQAQ LNMPLSEVCE GFDEEGRNIS
61 KTRGWHSPGR GSLDEGYKAS HKPEELDEHA LVELELHRGS SMEINLGEKD TASQIEAEKS
121 SSMSSLNIAK HMPHRAYWAE QQSRLPLPLM ELMENEALEI LTKALRSYQL GIGRDHFLTK
181 ELQRYIEGLK KRRSKRLYVNLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CATSPERZ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.6
- Highest tissue expression
- 545 nTPM
Expression across tissuesHPA
Tissue
- testis: 545 nTPM
- hippocampal formation: 3.5 nTPM
- amygdala: 3.2 nTPM
- cerebral cortex: 3 nTPM
- basal ganglia: 2.7 nTPM
- hypothalamus: 1.5 nTPM
Single-cell type
- late spermatids: 73 nCPM
- late primary spermatocytes: 22 nCPM
- early spermatids: 16 nCPM
- brain excitatory neurons: 3.3 nCPM
- brain inhibitory neurons: 2.6 nCPM
- astrocytes: 2.3 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebellum: 9.3 nTPM
- cerebral cortex: 8 nTPM
- hippocampal formation: 6.1 nTPM
- basal ganglia: 5.3 nTPM
- amygdala: 5.2 nTPM
- white matter: 5.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.02
- gnomAD pLI
- 0.02
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Cation channel sperm-associated auxiliary subunit zeta
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CATSPERZ in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CATSPERZ as an antibody target. Whether an autoantibody or antibody against CATSPERZ could matter depends on whether native CATSPERZ is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CATSPERZ is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CATSPERZ as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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