Seroatlas · Human Serome Atlas

CATSPER1

Cation channel sperm-associated protein 1

Also known as: CATSPER, CTSR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NEC5
Gene
CATSPER1
Ensembl
ENSG00000175294
Chromosome
11
Canonical length
780 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location
Principal piece

OverviewNCBI Gene

Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

780 residues, UniProt reviewed canonical sequence.

>Q8NEC5|CATSPER1
     1  MDQNSVPEKA QNEADTNNAD RFFRSHSSPP HHRPGHSRAL HHYELHHHGV PHQRGESHHP
    61  PEFQDFHDQA LSSHVHQSHH HSEARNHGRA HGPTGFGLAP SQGAVPSHRS YGEDYHDELQ
   121  RDGRRHHDGS QYGGFHQQSD SHYHRGSHHG RPQYLGENLS HYSSGVPHHG EASHHGGSYL
   181  PHGPNPYSES FHHSEASHLS GLQHDESQHH QVPHRGWPHH HQVHHHGRSR HHEAHQHGKS
   241  PHHGETISPH SSVGSYQRGI SDYHSEYHQG DHHPSEYHHG DHPHHTQHHY HQTHRHRDYH
   301  QHQDHHGAYH SSYLHGDYVQ STSQLSIPHT SRSLIHDAPG PAASRTGVFP YHVAHPRGSA
   361  HSMTRSSSTI RSRVTQMSKK VHTQDISTKH SEDWGKEEGQ FQKRKTGRLQ RTRKKGHSTN
   421  LFQWLWEKLT FLIQGFREMI RNLTQSLAFE TFIFFVVCLN TVMLVAQTFA EVEIRGEWYF
   481  MALDSIFFCI YVVEALLKII ALGLSYFFDF WNNLDFFIMA MAVLDFLLMQ THSFAIYHQS
   541  LFRILKVFKS LRALRAIRVL RRLSFLTSVQ EVTGTLGQSL PSIAAILILM FTCLFLFSAV
   601  LRALFRKSDP KRFQNIFTTI FTLFTLLTLD DWSLIYMDSR AQGAWYIIPI LVIYIIIQYF
   661  IFLNLVITVL VDSFQTALFK GLEKAKQERA ARIQEKLLED SLTELRAAEP KEVASEGTML
   721  KRLIEKKFGT MTEKQQELLF HYLQLVASVE QEQQKFRSQA AVIDEIVDTT FEAGEEDFRN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CATSPER1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • testis: 17 nTPM
  • blood vessel: 0.5 nTPM
  • bone marrow: 0.4 nTPM
  • lung: 0.4 nTPM
  • skin: 0.3 nTPM
  • appendix: 0.2 nTPM

Single-cell type

  • mast cells: 47 nCPM
  • early spermatids: 43 nCPM
  • late primary spermatocytes: 37 nCPM
  • platelets: 37 nCPM
  • monocytes: 18 nCPM
  • megakaryocytes: 12 nCPM

Immune cell

  • basophil: 17 nTPM
  • classical monocyte: 5.8 nTPM
  • NK-cell: 3.7 nTPM
  • myeloid DC: 2.4 nTPM
  • total PBMC: 2.3 nTPM
  • intermediate monocyte: 0.8 nTPM

Brain region

  • cerebellum: 0.6 nTPM
  • cerebral cortex: 0.4 nTPM
  • choroid plexus: 0.3 nTPM
  • basal ganglia: 0.2 nTPM
  • hippocampal formation: 0.2 nTPM
  • thalamus: 0.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CATSPER1.

Disease | AllUniProt

Conditions CATSPER1 is implicated in, by any mechanism.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 222 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.99
gnomAD pLI
0
gnomAD missense Z
0.65
DepMap mean gene effect
-0.17
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CATSPER1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CATSPER1 as an antibody target. Whether an autoantibody or antibody against CATSPER1 could matter depends on whether native CATSPER1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CATSPER1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CATSPER1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CATSPER1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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