Seroatlas · Human Serome Atlas

CATSPERD

Cation channel sperm-associated auxiliary subunit delta

Also known as: CTSRD_HUMAN, MGC39581, TMEM146

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86XM0
Gene: CATSPERD
Ensembl: ENSG00000174898
Chromosome: 19
Canonical length: 798 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Mid piece

OverviewNCBI Gene

Predicted to be involved in flagellated sperm motility and sperm capacitation. Predicted to be located in plasma membrane. Predicted to be part of CatSper complex. Predicted to be active in sperm principal piece. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

798 residues, UniProt reviewed canonical sequence.

>Q86XM0|CATSPERD
     1  MLMLMLVAAV TMWLRPLVTA QLCRSRTVRT GKVFNLIQDV QGDRLYFHPT TTRLIKHPCE
    61  KNIALYLGKQ VFFTMDNFET SLLPFTIPTS MQVGVPEVTS AHFAGSLLLL VVDQKVYIYD
   121  YENNSWSMSL GIKHPVTHVS GDNCCYTGSL FCVHVSNLVF AYFRGDQISQ TYIYYSNTGG
   181  FSFWKYHYDR QAEIIGSLGG IFHFFSLSQV AMLVVNQGKG MFKYSDHPLN RSFGLSFDYN
   241  GTLDILIAPG QRGILLLWFE NSLLFSHNAG QLVDTVRVKK GDQTLFSSIF EAKITIHNIA
   301  VTENELAVIT REDNLYYGNL GIVPSSIIKF ADQYIWSEDV ALMFRSPGTL EILTPLRDTA
   361  FPAFDFQKCL VNIQALLMDP ELHVGKCKIE FLTGEFIYRM YTIDMHSQLE LTASLIPQPG
   421  TSLIPLVMVS NPHSLGFQAT FYENGYTSDG NTKYKLDIFL KQQQHWGRTD SNFTSSLKKA
   481  TMSTLTVDIA NKEISCVDIK PLSTLISVGC DLDKKIVIQN KVSACSMGIL DPLTLQDNYS
   541  FIIEKEFYDP GFQGQQSSED LHVFYSYQQL GCPLLVYYDT LWKPVVELWR KDSFQEVIDA
   601  EYVLLEVNGQ FSYSYSLTAQ SAMCTSQPQN WTTMIKEFGG PFFWNRENYV SCHDPNNNAP
   661  LRWPDVQYQI LGGRTANQII FGHNGFYVFY ISIVDPYYSY CQLETIFSIY VYGAFPVQLV
   721  SAGVVILLII SSILGSVWLA YKTPKLLRTA RGRRIKKCAT QLCRRCKTVC QFRASATARA
   781  GTEPPGRHRT PHGGRSDH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CATSPERD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 8.1 nTPM

Expression across tissuesHPA

Tissue

testis: 8.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

fallopian tube ciliated cells: 251 nCPM
respiratory ciliated cells: 249 nCPM
late spermatids: 219 nCPM
epididymal efferent duct ciliated cells: 174 nCPM
early spermatids: 167 nCPM
endometrial ciliated cells: 91 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 0.9 nTPM
medulla oblongata: 0.7 nTPM
pons: 0.5 nTPM
spinal cord: 0.4 nTPM
hypothalamus: 0.3 nTPM
hippocampal formation: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.92
gnomAD pLI: 0
gnomAD missense Z: 0.23
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Cation channel sperm-associated auxiliary subunit delta/epsilon
CATSPERD/E, C-terminal domain
CATSPERD/E C-terminal domain
CATSPERD, beta-propeller domain
CATSPERD, Ig-like domain
CATSPERD, beta-propeller domain
CATSPERD Ig-like domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CATSPERD in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CATSPERB

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CATSPERD as an antibody target. Whether an autoantibody or antibody against CATSPERD could matter depends on whether native CATSPERD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CATSPERD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CATSPERD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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