MEIOB

Protein identityUniProt · HPA

UniProt accession

Q8N635

Gene

MEIOB

Ensembl

ENSG00000162039

Chromosome

16

Canonical length

442 aa

Protein class

Disease related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable chromatin binding activity; single-stranded DNA 3'-5' DNA exonuclease activity; and single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination; fertilization; and meiotic nuclear division. Located in nucleus. Implicated in primary ovarian insufficiency and spermatogenic failure 22. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

442 residues, UniProt reviewed canonical sequence.

>Q8N635|MEIOB
     1  MANSFAARIF TTLSDLQTNM ANLKVIGIVI GKTDVKGFPD RKNIGSERYT FSFTIRDSPA
    61  HFVNAASWGN EDYIKSLSDS FRVGDCVIIE NPLIQRKEIE REEKFSPATP SNCKLLLSEN
   121  HSTVKVCSSY EVDTKLLSLI HLPVKESHDY YSLGDIVANG HSLNGRIINV LAAVKSVGEP
   181  KYFTTSDRRK GQRCEVRLYD ETESSFAMTC WDNESILLAQ SWMPRETVIF ASDVRINFDK
   241  FRNCMTATVI SKTIITTNPD IPEANILLNF IRENKETNVL DDEIDSYFKE SINLSTIVDV
   301  YTVEQLKGKA LKNEGKADPS YGILYAYIST LNIDDETTKV VRNRCSSCGY IVNEASNMCT
   361  TCNKNSLDFK SVFLSFHVLI DLTDHTGTLH SCSLTGSVAE ETLGCTFVLS HRARSGLKIS
   421  VLSCKLADPT EASRNLSGQK HV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MEIOB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.31

Highest tissue expression

27 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MEIOB.

Disease | AllUniProt

Conditions MEIOB is implicated in, by any mechanism.

• Spermatogenic failure 22 (SPGF22) MIM:617706
• Premature ovarian failure 23 (POF23) MIM:620686

Disease | GeneticClinVar

12 pathogenic / likely-pathogenic of 102 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Spermatogenic failure 22
• Premature ovarian failure 23
• Azoospermia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.42

gnomAD pLI

0

gnomAD missense Z

0.89

DepMap mean gene effect

-0.08

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• double-strand break repair via homologous recombination
• female meiosis I
• fertilization
• homologous chromosome pairing at meiosis
• male meiosis I
• male meiotic nuclear division
• resolution of meiotic recombination intermediates

Molecular functions

• chromatin binding
• single-stranded DNA 3'-5' DNA exonuclease activity
• single-stranded DNA binding

Cellular components

• chromosome
• cytoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Nucleic acid-binding, OB-fold
• Meiosis-specific OB domain-containing
• MEIOB-like, N-terminal
• MEIOB, N-terminal

KeywordsUniProt

• Chromosome
• Cytoplasm
• DNA-binding
• Exonuclease
• Hydrolase
• Meiosis
• Nuclease
• Nucleus
• Premature ovarian failure

InteractionsUniProt · HPA

Protein binding partners of MEIOB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SPATA22
• HSF2BP
• BRCA2
• BRME1