Seroatlas · Human Serome Atlas

SPATA22

Spermatogenesis-associated protein 22

Also known as: NYD-SP20, SPT22_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NHS9
Gene: SPATA22
Ensembl: ENSG00000141255
Chromosome: 17
Canonical length: 363 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in regulation of meiotic cell cycle. Predicted to act upstream of or within several processes, including fertilization; gamete generation; and meiosis I cell cycle process. Predicted to be located in chromosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

363 residues, UniProt reviewed canonical sequence.

>Q8NHS9|SPATA22
     1  MKRSLNENSA RSTAGCLPVP LFNQKKRNRQ PLTSNPLKDD SGISTPSDNY DFPPLPTDWA
    61  WEAVNPELAP VMKTVDTGQI PHSVSRPLRS QDSVFNSIQS NTGRSQGGWS YRDGNKNTSL
   121  KTWNKNDFKP QCKRTNLVAN DGKNSCPVSS GAQQQKQLRI PEPPNLSRNK ETELLRQTHS
   181  SKISGCTMRG LDKNSALQTL KPNFQQNQYK KQMLDDIPED NTLKETSLYQ LQFKEKASSL
   241  RIISAVIESM KYWREHAQKT VLLFEVLAVL DSAVTPGPYY SKTFLMRDGK NTLPCVFYEI
   301  DRELPRLIRG RVHRCVGNYD QKKNIFQCVS VRPASVSEQK TFQAFVKIAD VEMQYYINVM
   361  NET

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPATA22 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 215 nTPM

Expression across tissuesHPA

Tissue

testis: 215 nTPM
placenta: 3.3 nTPM
parathyroid gland: 2.6 nTPM
adipose tissue: 1 nTPM
breast: 1 nTPM
midbrain: 1 nTPM

Single-cell type

late primary spermatocytes: 996 nCPM
early primary spermatocytes: 483 nCPM
late spermatids: 192 nCPM
early spermatids: 154 nCPM
oligodendrocytes: 87 nCPM
fibro-adipogenic progenitors: 79 nCPM

Immune cell

naive CD8 T-cell: 0.5 nTPM
naive CD4 T-cell: 0.4 nTPM
intermediate monocyte: 0.3 nTPM
MAIT T-cell: 0.2 nTPM
NK-cell: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM

Brain region

white matter: 9.4 nTPM
thalamus: 5.1 nTPM
medulla oblongata: 2.9 nTPM
basal ganglia: 2.7 nTPM
cerebral cortex: 2.6 nTPM
midbrain: 2.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SPATA22.

Disease | AllUniProt

Conditions SPATA22 is implicated in, by any mechanism.

Spermatogenic failure 96 (SPGF96) MIM:621001
Premature ovarian failure 25 (POF25) MIM:621002

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 60 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Premature ovarian failure 25
Spermatogenic failure 96

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0
gnomAD missense Z: 0.29
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

chromosome

Protein domainsUniProt · Pfam · InterPro

Spermatogenesis-associated protein 22

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SPATA22 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPATA22 as an antibody target. Whether an autoantibody or antibody against SPATA22 could matter depends on whether native SPATA22 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPATA22 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPATA22 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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