Seroatlas · Human Serome Atlas

AIMP2

Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

Also known as: AIMP2_HUMAN, JTV-1, JTV1, p38, PRO0992

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13155
Gene: AIMP2
Ensembl: ENSG00000106305
Chromosome: 7
Canonical length: 320 aa
Protein class: Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

The protein encoded by this gene is part of the aminoacyl-tRNA synthetase complex, which contains nine different aminoacyl-tRNA synthetases and three non-enzymatic factors. The encoded protein is one of the non-enzymatic factors and is required for assembly and stability of the complex. [provided by RefSeq, May 2016]

Canonical amino-acid sequenceUniProt

320 residues, UniProt reviewed canonical sequence.

>Q13155|AIMP2
     1  MPMYQVKPYH GGGAPLRVEL PTCMYRLPNV HGRSYGPAPG AGHVQEESNL SLQALESRQD
    61  DILKRLYELK AAVDGLSKMI QTPDADLDVT NIIQADEPTT LTTNALDLNS VLGKDYGALK
   121  DIVINANPAS PPLSLLVLHR LLCEHFRVLS TVHTHSSVKS VPENLLKCFG EQNKKQPRQD
   181  YQLGFTLIWK NVPKTQMKFS IQTMCPIEGE GNIARFLFSL FGQKHNAVNA TLIDSWVDIA
   241  IFQLKEGSSK EKAAVFRSMN SALGKSPWLA GNELTVADVV LWSVLQQIGG CSVTVPANVQ
   301  RWMRSCENLA PFNTALKLLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AIMP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 151 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 151 nTPM
tongue: 97 nTPM
duodenum: 46 nTPM
heart muscle: 43 nTPM
testis: 42 nTPM
liver: 32 nTPM

Single-cell type

late primary spermatocytes: 247 nCPM
oocytes: 124 nCPM
early spermatids: 121 nCPM
late spermatids: 111 nCPM
thymic myoid cells: 90 nCPM
esophageal basal cells: 87 nCPM

Immune cell

myeloid DC: 94 nTPM
intermediate monocyte: 79 nTPM
classical monocyte: 63 nTPM
plasmacytoid DC: 61 nTPM
non-classical monocyte: 60 nTPM
NK-cell: 50 nTPM

Brain region

white matter: 23 nTPM
cerebellum: 22 nTPM
hippocampal formation: 20 nTPM
medulla oblongata: 20 nTPM
spinal cord: 20 nTPM
thalamus: 20 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about AIMP2.

Disease | AllUniProt

Conditions AIMP2 is implicated in, by any mechanism.

Leukodystrophy, hypomyelinating, 17 (HLD17) MIM:618006

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 183 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Leukodystrophy, hypomyelinating, 17
Inborn genetic diseases
Neurodevelopmental abnormality

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0.01
gnomAD missense Z: -0.85
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein-macromolecule adaptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Glutathione S-transferase, C-terminal
Glutathione S-transferase, C-terminal domain superfamily
Glutathione S-transferase, C-terminal domain
AIMP2, lysyl-tRNA synthetase binding domain
AIMP2, thioredoxin-like domain
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
AIMP2 lysyl-tRNA synthetase binding domain
Thioredoxin-like domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AIMP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AIMP2 as an antibody target. Whether an autoantibody or antibody against AIMP2 could matter depends on whether native AIMP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AIMP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AIMP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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