Seroatlas · Human Serome Atlas

HSBP1

Heat shock factor-binding protein 1

Also known as: HSBP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75506
Gene
HSBP1
Ensembl
ENSG00000230989
Chromosome
16
Canonical length
76 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli
Quaternary structure
Homohexamer

OverviewNCBI Gene

The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

76 residues, UniProt reviewed canonical sequence.

>O75506|HSBP1
     1  MAETDPKTVQ DLTSVVQTLL QQMQDKFQTM SDQIIGRIDD MSSRIDDLEK NIADLMTQAG
    61  VEELESENKI PATQKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSBP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
36 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 36 nTPM
  • skeletal muscle: 18 nTPM
  • parathyroid gland: 18 nTPM
  • tongue: 17 nTPM
  • ovary: 16 nTPM
  • cerebral cortex: 14 nTPM

Single-cell type

  • esophageal apical cells: 1,105 nCPM
  • late primary spermatocytes: 854 nCPM
  • esophageal suprabasal cells: 385 nCPM
  • epididymal efferent duct ciliated cells: 381 nCPM
  • extravillous trophoblasts: 299 nCPM
  • respiratory ciliated cells: 286 nCPM

Immune cell

  • neutrophil: 75 nTPM
  • eosinophil: 69 nTPM
  • total PBMC: 64 nTPM
  • intermediate monocyte: 58 nTPM
  • non-classical monocyte: 56 nTPM
  • classical monocyte: 52 nTPM

Brain region

  • hypothalamus: 16 nTPM
  • cerebral cortex: 16 nTPM
  • white matter: 15 nTPM
  • thalamus: 14 nTPM
  • spinal cord: 14 nTPM
  • medulla oblongata: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.4
gnomAD pLI
0.23
gnomAD missense Z
0.58
DepMap mean gene effect
-0.26
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HSBP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HSBP1 as an antibody target. Whether an autoantibody or antibody against HSBP1 could matter depends on whether native HSBP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HSBP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HSBP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HSBP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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