Seroatlas · Human Serome Atlas

ABRAXAS1

BRCA1-A complex subunit Abraxas 1

Also known as: ABRA1, ABRAXAS, ABRX1_HUMAN, CCDC98, FAM175A, FLJ13614

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6UWZ7
Gene
ABRAXAS1
Ensembl
ENSG00000163322
Chromosome
4
Canonical length
409 aa
Protein class
Disease related genes, Predicted intracellular proteins
Subcellular location
Nuclear bodies
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a protein that binds to the C-terminal repeats of breast cancer 1 (BRCA1) through a phospho-SXXF motif. The encoded protein recruits ubiquitin interaction motif containing 1 protein to BRCA1 protein and is required for DNA damage resistance, DNA repair, and cell cycle checkpoint control. Pseudogenes of this gene are found on chromosomes 3 and 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

409 residues, UniProt reviewed canonical sequence.

>Q6UWZ7|ABRAXAS1
     1  MEGESTSAVL SGFVLGALAF QHLNTDSDTE GFLLGEVKGE AKNSITDSQM DDVEVVYTID
    61  IQKYIPCYQL FSFYNSSGEV NEQALKKILS NVKKNVVGWY KFRRHSDQIM TFRERLLHKN
   121  LQEHFSNQDL VFLLLTPSII TESCSTHRLE HSLYKPQKGL FHRVPLVVAN LGMSEQLGYK
   181  TVSGSCMSTG FSRAVQTHSS KFFEEDGSLK EVHKINEMYA SLQEELKSIC KKVEDSEQAV
   241  DKLVKDVNRL KREIEKRRGA QIQAAREKNI QKDPQENIFL CQALRTFFPN SEFLHSCVMS
   301  LKNRHVSKSS CNYNHHLDVV DNLTLMVEHT DIPEASPAST PQIIKHKALD LDDRWQFKRS
   361  RLLDTQDKRS KADTGSSNQD KASKMSSPET DEEIEKMKGF GEYSRSPTF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABRAXAS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
10 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 10 nTPM
  • testis: 10 nTPM
  • lymph node: 7.4 nTPM
  • bone marrow: 7.2 nTPM
  • thyroid gland: 6.9 nTPM
  • endometrium: 6 nTPM

Single-cell type

  • early primary spermatocytes: 149 nCPM
  • differentiating spermatogonia: 113 nCPM
  • early spermatids: 86 nCPM
  • choroid plexus epithelial cells: 80 nCPM
  • late primary spermatocytes: 80 nCPM
  • late spermatids: 72 nCPM

Immune cell

  • naive CD4 T-cell: 5.3 nTPM
  • NK-cell: 4.7 nTPM
  • naive CD8 T-cell: 4.2 nTPM
  • basophil: 3.5 nTPM
  • memory CD4 T-cell: 3.4 nTPM
  • T-reg: 3.2 nTPM

Brain region

  • choroid plexus: 44 nTPM
  • cerebellum: 34 nTPM
  • white matter: 29 nTPM
  • cerebral cortex: 25 nTPM
  • basal ganglia: 25 nTPM
  • midbrain: 25 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ABRAXAS1.

Disease | AllUniProt

Conditions ABRAXAS1 is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.01
gnomAD pLI
0
DepMap mean gene effect
-0.3
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ABRAXAS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ABRAXAS1 as an antibody target. Whether an autoantibody or antibody against ABRAXAS1 could matter depends on whether native ABRAXAS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ABRAXAS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ABRAXAS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ABRAXAS1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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