ACAA2

Protein identityUniProt · HPA

UniProt accession

P42765

Gene

ACAA2

Ensembl

ENSG00000167315

Chromosome

18

Canonical length

397 aa

Protein class

Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

Subcellular location

Nuclear bodies,Mitochondria,Basal body

Quaternary structure

Homotetramer

OverviewNCBI Gene

The encoded protein catalyzes the last step of the mitochondrial fatty acid beta-oxidation spiral. Unlike most mitochondrial matrix proteins, it contains a non-cleavable amino-terminal targeting signal. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

397 residues, UniProt reviewed canonical sequence.

>P42765|ACAA2
     1  MALLRGVFVV AAKRTPFGAY GGLLKDFTAT DLSEFAAKAA LSAGKVSPET VDSVIMGNVL
    61  QSSSDAIYLA RHVGLRVGIP KETPALTINR LCGSGFQSIV NGCQEICVKE AEVVLCGGTE
   121  SMSQAPYCVR NVRFGTKLGS DIKLEDSLWV SLTDQHVQLP MAMTAENLAV KHKISREECD
   181  KYALQSQQRW KAANDAGYFN DEMAPIEVKT KKGKQTMQVD EHARPQTTLE QLQKLPPVFK
   241  KDGTVTAGNA SGVADGAGAV IIASEDAVKK HNFTPLARIV GYFVSGCDPS IMGIGPVPAI
   301  SGALKKAGLS LKDMDLVEVN EAFAPQYLAV ERSLDLDISK TNVNGGAIAL GHPLGGSGSR
   361  ITAHLVHELR RRGGKYAVGS ACIGGGQGIA VIIQSTA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACAA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.21

Highest tissue expression

946 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.31

gnomAD pLI

0

gnomAD missense Z

-0.27

DepMap mean gene effect

0.08

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular response to hypoxia
• cholesterol biosynthetic process
• fatty acid beta-oxidation
• negative regulation of mitochondrial membrane permeability involved in apoptotic process
• negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

Molecular functions

• acetyl-CoA C-acetyltransferase activity
• acetyl-CoA C-acyltransferase activity
• acetyl-CoA hydrolase activity
• fatty acyl-CoA hydrolase activity
• RNA binding

Cellular components

• ciliary basal body
• mitochondrial matrix
• mitochondrion
• nuclear body

Protein domainsUniProt · Pfam · InterPro

• Thiolase
• Thiolase-like
• Thiolase, active site
• Thiolase, conserved site
• Thiolase, acyl-enzyme intermediate active site
• Thiolase, N-terminal
• Thiolase, C-terminal
• Thiolase, N-terminal domain
• Thiolase, C-terminal domain

KeywordsUniProt

• Acetylation
• Acyltransferase
• Fatty acid metabolism
• Hydrolase
• Lipid metabolism
• Mitochondrion
• Phosphoprotein
• Transferase
• Transit peptide

InteractionsUniProt · HPA

Protein binding partners of ACAA2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• BNIP3
• TRMT61B