Seroatlas · Human Serome Atlas

BCL2L2

Bcl-2-like protein 2

Also known as: B2CL2_HUMAN, BCL-W, BCL2L2-PABPN1, KIAA0271, PPP1R51

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92843
Gene
BCL2L2
Ensembl
ENSG00000129473
Chromosome
14
Canonical length
193 aa
Protein class
Cancer-related genes, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

193 residues, UniProt reviewed canonical sequence.

>Q92843|BCL2L2
     1  MATPASAPDT RALVADFVGY KLRQKGYVCG AGPGEGPAAD PLHQAMRAAG DEFETRFRRT
    61  FSDLAAQLHV TPGSAQQRFT QVSDELFQGG PNWGRLVAFF VFGAALCAES VNKEMEPLVG
   121  QVQEWMVAYL ETQLADWIHS SGGWAEFTAL YGDGALEEAR RLREGNWASV RTVLTGAVAL
   181  GALVTVGAFF ASK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BCL2L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
104 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 104 nTPM
  • midbrain: 103 nTPM
  • cerebral cortex: 92 nTPM
  • amygdala: 86 nTPM
  • colon: 84 nTPM
  • hippocampal formation: 80 nTPM

Single-cell type

  • cardiomyocytes: 354 nCPM
  • adipocytes: 65 nCPM
  • epicardial cells: 43 nCPM
  • early spermatids: 26 nCPM
  • other brain neurons: 24 nCPM
  • brain excitatory neurons: 23 nCPM

Immune cell

  • classical monocyte: 0.4 nTPM
  • intermediate monocyte: 0.3 nTPM
  • memory B-cell: 0.3 nTPM
  • myeloid DC: 0.3 nTPM
  • total PBMC: 0.3 nTPM
  • non-classical monocyte: 0.2 nTPM

Brain region

  • thalamus: 141 nTPM
  • amygdala: 127 nTPM
  • spinal cord: 124 nTPM
  • medulla oblongata: 118 nTPM
  • basal ganglia: 109 nTPM
  • midbrain: 109 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.83
gnomAD pLI
0.47
gnomAD missense Z
1.05
DepMap mean gene effect
-0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BCL2L2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BCL2L2 as an antibody target. Whether an autoantibody or antibody against BCL2L2 could matter depends on whether native BCL2L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BCL2L2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BCL2L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BCL2L2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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