Seroatlas · Human Serome Atlas

RTL10

Protein Bop

Also known as: BOP, BOP_HUMAN, C22orf29, FLJ21125

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7L3V2
Gene: RTL10
Ensembl: ENSG00000215012
Chromosome: 22
Canonical length: 364 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Involved in mitochondrial outer membrane permeabilization and regulation of mitochondrial membrane potential. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

364 residues, UniProt reviewed canonical sequence.

>Q7L3V2|RTL10
     1  MPRGRCRQQG PRIPIWAAAN YANAHPWQQM DKASPGVAYT PLVDPWIERP CCGDTVCVRT
    61  TMEQKSTASG TCGGKPAERG PLAGHMPSSR PHRVDFCWVP GSDPGTFDGS PWLLDRFLAQ
   121  LGDYMSFHFE HYQDNISRVC EILRRLTGRA QAWAAPYLDG DLPLPDDYEL FCQDLKEVVQ
   181  DPNSFAEYHA VVTCPLPLAS SQLPVAPQLP VVRQYLARFL EGLALDMGTA PRSLPAAMAT
   241  PAVSGSNSVS RSALFEQQLT KESTPGPKEP PVLPSSTCSS KPGPVEPASS QPEEAAPTPV
   301  PRLSESANPP AQRPDPAHPG GPKPQKTEEE VLETEGDQEV SLGTPQEVVE APETPGEPPL
   361  SPGF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RTL10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

skin: 13 nTPM
thymus: 10 nTPM
fallopian tube: 8.3 nTPM
cerebral cortex: 7.6 nTPM
pancreas: 6.9 nTPM
duodenum: 6.7 nTPM

Single-cell type

basal prostatic cells: 0.3 nCPM
prostatic glandular cells: 0.3 nCPM
thyrotrophs: 0.3 nCPM
alveolar cells type 1: 0.2 nCPM
basal keratinocytes: 0.2 nCPM
breast lactating cells: 0.2 nCPM

Immune cell

non-classical monocyte: 4 nTPM
naive CD4 T-cell: 3.9 nTPM
eosinophil: 3.1 nTPM
naive CD8 T-cell: 3 nTPM
T-reg: 3 nTPM
basophil: 2.6 nTPM

Brain region

cerebral cortex: 20 nTPM
hippocampal formation: 18 nTPM
basal ganglia: 17 nTPM
cerebellum: 16 nTPM
hypothalamus: 15 nTPM
white matter: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0
gnomAD pLI: 0
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

mitochondrion

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RTL10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RTL10 as an antibody target. Whether an autoantibody or antibody against RTL10 could matter depends on whether native RTL10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RTL10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RTL10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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