Seroatlas · Human Serome Atlas

MC4R

Melanocortin receptor 4

Also known as: MC4R_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P32245
Gene
MC4R
Ensembl
ENSG00000166603
Chromosome
18
Canonical length
332 aa
Protein class
Disease related genes, FDA approved drug targets, G-protein coupled receptors, Human disease related genes, Predicted membrane proteins, Transporters
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. [provided by RefSeq, Jan 2010]

Canonical amino-acid sequenceUniProt

332 residues, UniProt reviewed canonical sequence.

>P32245|MC4R
     1  MVNSTHRGMH TSLHLWNRSS YRLHSNASES LGKGYSDGGC YEQLFVSPEV FVTLGVISLL
    61  ENILVIVAIA KNKNLHSPMY FFICSLAVAD MLVSVSNGSE TIVITLLNST DTDAQSFTVN
   121  IDNVIDSVIC SSLLASICSL LSIAVDRYFT IFYALQYHNI MTVKRVGIII SCIWAACTVS
   181  GILFIIYSDS SAVIICLITM FFTMLALMAS LYVHMFLMAR LHIKRIAVLP GTGAIRQGAN
   241  MKGAITLTIL IGVFVVCWAP FFLHLIFYIS CPQNPYCVCF MSHFNLYLIL IMCNSIIDPL
   301  IYALRSQELR KTFKEIICCY PLGGLCDLSS RY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MC4R can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
3.6 nTPM

Expression across tissuesHPA

Tissue

  • retina: 3.6 nTPM
  • hypothalamus: 3.5 nTPM
  • fallopian tube: 2.9 nTPM
  • basal ganglia: 2.6 nTPM
  • cerebral cortex: 1.8 nTPM
  • amygdala: 0.8 nTPM

Single-cell type

  • other brain neurons: 12 nCPM
  • retinal bipolar cells: 6.4 nCPM
  • cone photoreceptor cells: 2.1 nCPM
  • brain inhibitory neurons: 2 nCPM
  • fallopian secretory cells: 1.9 nCPM
  • bergmann glia: 1.5 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 7.4 nTPM
  • basal ganglia: 4.8 nTPM
  • cerebral cortex: 4.8 nTPM
  • midbrain: 3.1 nTPM
  • white matter: 2.5 nTPM
  • medulla oblongata: 2.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MC4R.

Disease | AllUniProt

Conditions MC4R is implicated in, by any mechanism.

Disease | GeneticClinVar

61 pathogenic / likely-pathogenic of 283 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.6
gnomAD pLI
0
gnomAD missense Z
-1.01
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MC4R in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MC4R as an antibody target. Whether an autoantibody or antibody against MC4R could matter depends on whether native MC4R is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MC4R is annotated at the cell surface, where native MC4R is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MC4R as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MC4R. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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