Seroatlas · Human Serome Atlas

NKAIN1

Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1

Also known as: FAM77C, FLJ12650, NKAI1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q4KMZ8
Gene: NKAIN1
Ensembl: ENSG00000084628
Chromosome: 1
Canonical length: 207 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

NKAIN1 is a member of a family of mammalian proteins with similarity to Drosophila Nkain and interacts with the beta subunit of Na,K-ATPase (ATP1B1; MIM 182330) (Gorokhova et al., 2007 [PubMed 17606467]).[supplied by OMIM, Jun 2009]

Canonical amino-acid sequenceUniProt

207 residues, UniProt reviewed canonical sequence.

>Q4KMZ8|NKAIN1
     1  MGKCSGRCTL VAFCCLQLVA ALERQIFDFL GYQWAPILAN FLHIMAVILG IFGTVQYRSR
    61  YLILYAAWLV LWVGWNAFII CFYLEVGQLS QDRDFIMTFN TSLHRSWWME NGPGCLVTPV
   121  LNSRLALEDH HVISVTGCLL DYPYIEALSS ALQIFLALFG FVFACYVSKV FLEEEDSFDF
   181  IGGFDSYGYQ APQKTSHLQL QPLYTSG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NKAIN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 28 nTPM
adrenal gland: 22 nTPM
skeletal muscle: 18 nTPM
tongue: 11 nTPM
basal ganglia: 7 nTPM
hippocampal formation: 6.8 nTPM

Single-cell type

adrenal medulla cells: 64 nCPM
adrenal cortex cells: 44 nCPM
oligodendrocytes: 39 nCPM
myonuclei: 32 nCPM
epididymal efferent duct absorptive cells: 29 nCPM
brain excitatory neurons: 29 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 38 nTPM
white matter: 35 nTPM
cerebellum: 32 nTPM
midbrain: 31 nTPM
basal ganglia: 28 nTPM
medulla oblongata: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.66
gnomAD pLI: 0.25
gnomAD missense Z: 1.58
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NKAIN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ATP1B1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NKAIN1 as an antibody target. Whether an autoantibody or antibody against NKAIN1 could matter depends on whether native NKAIN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NKAIN1 is annotated at the cell surface, where native NKAIN1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NKAIN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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