Seroatlas · Human Serome Atlas

NKAIN3

Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3

Also known as: FAM77D, FLJ39630, NKAI3_HUMAN, NKAIN3-IT1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N8D7
Gene: NKAIN3
Ensembl: ENSG00000185942
Chromosome: 8
Canonical length: 197 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

NKAIN3 is a member of a family of mammalian proteins (see NKAIN1; MIM 612871) with similarity to Drosophila Nkain (Gorokhova et al., 2007 [PubMed 17606467]).[supplied by OMIM, Jun 2009]

Canonical amino-acid sequenceUniProt

197 residues, UniProt reviewed canonical sequence.

>Q8N8D7|NKAIN3
     1  MGCCTGRCSL ICLCALQLVS ALERQIFDFL GFQWAPILGN FLHIIVVILG LFGTIQYRPR
    61  YIMVYTVWTA LWVTWNVFII CFYLEVGGLS KDTDLMTFNI SVHRSWWREH GPGCVRRVLP
   121  PSAHGMMDDY TYVSVTGCIV DFQYLEVIHS AVQILLSLVG FVYACYVISI SMEEEDTYSC
   181  DLQVCKHLFI QMLQIIE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NKAIN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

amygdala: 10 nTPM
basal ganglia: 8.9 nTPM
cerebral cortex: 8.7 nTPM
hippocampal formation: 5.3 nTPM
hypothalamus: 3.8 nTPM
midbrain: 3.7 nTPM

Single-cell type

astrocytes: 2,222 nCPM
oligodendrocyte progenitor cells: 878 nCPM
schwann cells: 604 nCPM
adrenal cortex cells: 572 nCPM
other brain neurons: 394 nCPM
brain excitatory neurons: 269 nCPM

Immune cell

basophil: 0.9 nTPM
neutrophil: 0.5 nTPM
gdT-cell: 0.2 nTPM
naive B-cell: 0.2 nTPM
NK-cell: 0.2 nTPM
non-classical monocyte: 0.2 nTPM

Brain region

amygdala: 69 nTPM
hippocampal formation: 64 nTPM
hypothalamus: 64 nTPM
midbrain: 55 nTPM
basal ganglia: 55 nTPM
cerebral cortex: 53 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.79
gnomAD pLI: 0.05
gnomAD missense Z: 1.26
DepMap mean gene effect: 0.13
DepMap dependency class: selective

OntologyGO

Biological processes

regulation of sodium ion transport

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NKAIN3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ATP1B1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NKAIN3 as an antibody target. Whether an autoantibody or antibody against NKAIN3 could matter depends on whether native NKAIN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NKAIN3 is annotated at the cell surface, where native NKAIN3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NKAIN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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