NKAIN2

Protein identityUniProt · HPA

UniProt accession

Q5VXU1

Gene

NKAIN2

Ensembl

ENSG00000188580

Chromosome

6

Canonical length

208 aa

Protein class

Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters

Subcellular location

Cytosol

OverviewNCBI Gene

This gene encodes a transmembrane protein that interacts with the beta subunit of a sodium/potassium-transporting ATPase. A chromosomal translocation involving this gene is a cause of lymphoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

208 residues, UniProt reviewed canonical sequence.

>Q5VXU1|NKAIN2
     1  MGYCSGRCTL IFICGMQLVC VLERQIFDFL GYQWAPILAN FVHIIIVILG LFGTIQYRPR
    61  YITGYAVWLV LWVTWNVFVI CFYLEAGDLS KETDLILTFN ISMHRSWWME NGPGCTVTSV
   121  TPAPDWAPED HRYITVSGCL LEYQYIEVAH SSLQIVLALA GFIYACYVVK CITEEEDSFD
   181  FIGGFDSYGY QGPQKTSHLQ LQPMYMSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NKAIN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

4

Mean surface accessibility (rSASA)

0.36

Highest tissue expression

84 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NKAIN2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 27 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• See cases

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.77

gnomAD pLI

0.02

gnomAD missense Z

1.02

DepMap mean gene effect

0.05

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• regulation of sodium ion transport

Cellular components

• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Na,K-Atpase Interacting protein
• Na,K-Atpase Interacting protein

KeywordsUniProt

• Cell membrane
• Chromosomal rearrangement
• Membrane
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of NKAIN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ATP1B1