Seroatlas · Human Serome Atlas

NKAIN4

Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4

Also known as: bA261N11.2, C20orf58, FAM77A, NKAI4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IVV8
Gene: NKAIN4
Ensembl: ENSG00000101198
Chromosome: 20
Canonical length: 208 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

NKAIN4 is a member of a family of mammalian proteins (see NKAIN1; MIM 612871) with similarity to Drosophila Nkain and interacts with the beta subunit of Na,K-ATPase (ATP1B1; MIM 182330) (Gorokhova et al., 2007 [PubMed 17606467]).[supplied by OMIM, Jun 2009]

Canonical amino-acid sequenceUniProt

208 residues, UniProt reviewed canonical sequence.

>Q8IVV8|NKAIN4
     1  MGSCSGRCAL VVLCAFQLVA ALERQVFDFL GYQWAPILAN FVHIIIVILG LFGTIQYRLR
    61  YVMVYTLWAA VWVTWNVFII CFYLEVGGLL KDSELLTFSL SRHRSWWRER WPGCLHEEVP
   121  AVGLGAPHGQ ALVSGAGCAL EPSYVEALHS CLQILIALLG FVCGCQVVSV FTEEEDSFDF
   181  IGGFDPFPLY HVNEKPSSLL SKQVYLPA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NKAIN4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 89 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 89 nTPM
amygdala: 78 nTPM
midbrain: 69 nTPM
cerebral cortex: 69 nTPM
hypothalamus: 58 nTPM
hippocampal formation: 56 nTPM

Single-cell type

oligodendrocyte progenitor cells: 120 nCPM
astrocytes: 116 nCPM
müller glia: 86 nCPM
bergmann glia: 85 nCPM
proximal tubule cells: 46 nCPM
epididymal efferent duct absorptive cells: 43 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hippocampal formation: 56 nTPM
hypothalamus: 55 nTPM
amygdala: 46 nTPM
basal ganglia: 46 nTPM
thalamus: 46 nTPM
midbrain: 46 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.99
gnomAD pLI: 0.01
gnomAD missense Z: -0.06
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of sodium ion transport

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NKAIN4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ATP1B1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NKAIN4 as an antibody target. Whether an autoantibody or antibody against NKAIN4 could matter depends on whether native NKAIN4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NKAIN4 is annotated at the cell surface, where native NKAIN4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NKAIN4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...