Arrestin domain-containing protein
IPR050357
Definition
This family of proteins is involved in various cellular processes including endocytosis, ubiquitination, and signal transduction [[cite:PMID:20559325], [cite:PMID:21982743], [cite:PMID:23208550]]. Members act as adapter proteins, mediating the interaction between ubiquitin ligases and their substrates, which can lead to the ubiquitination and subsequent degradation of target proteins. Some proteins in this family are implicated in the regulation of G protein-coupled receptors (GPCRs) by affecting their cell surface expression and turnover. Others are involved in cellular responses to environmental stimuli, such as pH changes, by participating in the proteolytic cleavage of transcription factors PMID:10821185. Additionally, certain members have roles in oxidative stress response, transcriptional repression, cell cycle arrest, and tumor suppression. The family also includes proteins that contribute to the maturation of immune cells and the resistance to toxins and stress.
6 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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