MICOS10
MICOS complex subunit MIC10
Also known as: C1orf151, FLJ36999, Mic10, MIC10_HUMAN, MINOS1, MIO10, RP5-1056L3.2
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5TGZ0
- Gene
- MICOS10
- Ensembl
- ENSG00000173436
- Chromosome
- 1
- Canonical length
- 78 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins, Transporters
- Subcellular location
- Mitochondria
OverviewNCBI Gene
Involved in cristae formation. Located in mitochondrion. Part of MIB complex; MICOS complex; and SAM complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
78 residues, UniProt reviewed canonical sequence.
>Q5TGZ0|MICOS10
1 MSESELGRKW DRCLADAVVK IGTGFGLGIV FSLTFFKRRM WPLAFGSGMG LGMAYSNCQH
61 DFQAPYLLHG KYVKEQEQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MICOS10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.53
- Highest tissue expression
- 16 nTPM
Expression across tissuesHPA
Tissue
- tongue: 16 nTPM
- cerebral cortex: 14 nTPM
- heart muscle: 14 nTPM
- amygdala: 14 nTPM
- skeletal muscle: 13 nTPM
- hypothalamus: 12 nTPM
Single-cell type
- parietal cells: 879 nCPM
- gastric progenitor cells: 593 nCPM
- microglia: 381 nCPM
- enteric transient amplifying cells: 358 nCPM
- colonocytes: 344 nCPM
- enterocytes: 270 nCPM
Immune cell
- non-classical monocyte: 7 nTPM
- intermediate monocyte: 6.6 nTPM
- naive CD4 T-cell: 6.3 nTPM
- total PBMC: 5.9 nTPM
- eosinophil: 5.7 nTPM
- myeloid DC: 5 nTPM
Brain region
- hypothalamus: 18 nTPM
- pons: 17 nTPM
- medulla oblongata: 16 nTPM
- thalamus: 15 nTPM
- cerebral cortex: 14 nTPM
- midbrain: 14 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.58
- gnomAD pLI
- 0.79
- DepMap mean gene effect
- -0.42
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- MICOS complex subunit Mic10
- Domain of unknown function (DUF543)
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of MICOS10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MICOS10 as an antibody target. Whether an autoantibody or antibody against MICOS10 could matter depends on whether native MICOS10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MICOS10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label MICOS10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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