Seroatlas · Human Serome Atlas

MTX1

Metaxin-1

Also known as: MTX, MTX1_HUMAN, MTXN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13505
Gene: MTX1
Ensembl: ENSG00000173171
Chromosome: 1
Canonical length: 466 aa
Protein class: Predicted membrane proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to be involved in mitochondrion organization. Located in mitochondrion. Part of SAM complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

466 residues, UniProt reviewed canonical sequence.

>Q13505|MTX1
     1  MLLGGPPRSP RSGTSPKGPW SSTGHVQFGK SPQTWPRRTR PRSPEPAAPS GVRGSTWTRR
    61  RDSPRRAGPT ALSRYVGHLW MGRRPPSPEA RGPVPRSSAA SRARRSLASP GISPGPLTAT
   121  IGGAVAGGGP RQGRAEAHKE VFPGQRVGKM AAPMELFCWS GGWGLPSVDL DSLAVLTYAR
   181  FTGAPLKVHK ISNPWQSPSG TLPALRTSHG EVISVPHKII THLRKEKYNA DYDLSARQGA
   241  DTLAFMSLLE EKLLPVLVHT FWIDTKNYVE VTRKWYAEAM PFPLNFFLPG RMQRQYMERL
   301  QLLTGEHRPE DEEELEKELY REARECLTLL SQRLGSQKFF FGDAPASLDA FVFSYLALLL
   361  QAKLPSGKLQ VHLRGLHNLC AYCTHILSLY FPWDGAEVPP QRQTPAGPET EEEPYRRRNQ
   421  ILSVLAGLAA MVGYALLSGI VSIQRATPAR APGTRTLGMA EEDEEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MTX1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 87 nTPM

Expression across tissuesHPA

Tissue

testis: 87 nTPM
choroid plexus: 47 nTPM
liver: 43 nTPM
bone marrow: 37 nTPM
parathyroid gland: 35 nTPM
kidney: 33 nTPM

Single-cell type

epicardial cells: 39 nCPM
cardiomyocytes: 19 nCPM
late spermatids: 12 nCPM
kupffer cells: 8.2 nCPM
adipocytes: 8.1 nCPM
early spermatids: 7.8 nCPM

Immune cell

neutrophil: 115 nTPM
classical monocyte: 69 nTPM
myeloid DC: 61 nTPM
memory B-cell: 42 nTPM
total PBMC: 41 nTPM
T-reg: 39 nTPM

Brain region

choroid plexus: 22 nTPM
cerebellum: 13 nTPM
white matter: 13 nTPM
thalamus: 12 nTPM
medulla oblongata: 12 nTPM
midbrain: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.72
gnomAD pLI: 0.01
gnomAD missense Z: -0.19
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MTX1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ARMC1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MTX1 as an antibody target. Whether an autoantibody or antibody against MTX1 could matter depends on whether native MTX1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MTX1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MTX1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...