Seroatlas · Human Serome Atlas

APBB2

Amyloid beta precursor protein binding family B member 2

Also known as: APBB2_HUMAN, FE65L, FE65L1, MGC35575

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92870
Gene: APBB2
Ensembl: ENSG00000163697
Chromosome: 4
Canonical length: 758 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

758 residues, UniProt reviewed canonical sequence.

>Q92870|APBB2
     1  MSEVLPADSG VDTLAVFMAS SGTTDVTNRN SPATPPNTLN LRSSHNELLN AEIKHTETKN
    61  STPPKCRKKY ALTNIQAAMG LSDPAAQPLL GNGSANIKLV KNGENQLRKA AEQGQQDPNK
   121  NLSPTAVINI TSEKLEGKEP HPQDSSSCEI LPSQPRRTKS FLNYYADLET SARELEQNRG
   181  NHHGTAEEKS QPVQGQASTI IGNGDLLLQK PNRPQSSPED GQVATVSSSP ETKKDHPKTG
   241  AKTDCALHRI QNLAPSDEES SWTTLSQDSA SPSSPDETDI WSDHSFQTDP DLPPGWKRVS
   301  DIAGTYYWHI PTGTTQWERP VSIPADLQGS RKGSLSSVTP SPTPENEKQP WSDFAVLNGG
   361  KINSDIWKDL HAATVNPDPS LKEFEGATLR YASLKLRNAP HPDDDDSCSI NSDPEAKCFA
   421  VRSLGWVEMA EEDLAPGKSS VAVNNCIRQL SYCKNDIRDT VGIWGEGKDM YLILENDMLS
   481  LVDPMDRSVL HSQPIVSIRV WGVGRDNGRD FAYVARDKDT RILKCHVFRC DTPAKAIATS
   541  LHEICSKIMA ERKNAKALAC SSLQERANVN LDVPLQVDFP TPKTELVQKF HVQYLGMLPV
   601  DKPVGMDILN SAIENLMTSS NKEDWLSVNM NVADATVTVI SEKNEEEVLV ECRVRFLSFM
   661  GVGKDVHTFA FIMDTGNQRF ECHVFWCEPN AGNVSEAVQA ACMLRYQKCL VARPPSQKVR
   721  PPPPPADSVT RRVTTNVKRG VLSLIDTLKQ KRPVTEMP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against APBB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 39 nTPM
thyroid gland: 31 nTPM
spinal cord: 30 nTPM
cerebral cortex: 29 nTPM
skeletal muscle: 27 nTPM
blood vessel: 25 nTPM

Single-cell type

podocytes: 1,784 nCPM
distal convoluted tubule cells: 1,638 nCPM
oligodendrocytes: 1,047 nCPM
oligodendrocyte progenitor cells: 972 nCPM
alveolar cells type 1: 927 nCPM
adipocytes: 752 nCPM

Immune cell

naive B-cell: 5.5 nTPM
memory B-cell: 0.3 nTPM
basophil: 0.2 nTPM
classical monocyte: 0.2 nTPM
myeloid DC: 0.2 nTPM
total PBMC: 0.2 nTPM

Brain region

white matter: 179 nTPM
medulla oblongata: 124 nTPM
basal ganglia: 120 nTPM
midbrain: 116 nTPM
pons: 115 nTPM
cerebellum: 114 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.44
gnomAD pLI: 0.07
gnomAD missense Z: 2.12
DepMap mean gene effect: 0.16
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of APBB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads APBB2 as an antibody target. Whether an autoantibody or antibody against APBB2 could matter depends on whether native APBB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

APBB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label APBB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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