Seroatlas · Human Serome Atlas

APBB3

Amyloid-beta A4 precursor protein-binding family B member 3

Also known as: APBB3_HUMAN, FE65L2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95704
Gene: APBB3
Ensembl: ENSG00000113108
Chromosome: 5
Canonical length: 486 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear bodies,Actin filaments,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the APBB protein family. It is found in the cytoplasm and binds to the intracellular domain of the Alzheimer's disease beta-amyloid precursor protein (APP) as well as to other APP-like proteins. It is thought that the protein encoded by this gene may modulate the internalization of APP. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

486 residues, UniProt reviewed canonical sequence.

>O95704|APBB3
     1  MLGKDYMLAI ILVNCDDDLW GDHSLEVEAG LPPGWRKIHD AAGTYYWHVP SGSTQWQRPT
    61  WELGDAEDPG TGTEGIWGLR PPKGRSFSSL ESSLDRSNSL SWYGGESYIQ SMEPGAKCFA
   121  VRSLGWVEVP EEDLAPGKSS IAVNNCIQQL AQTRSRSQPP DGAWGEGQNM LMILKKDAMS
   181  LVNPLDHSLI HCQPLVHIRV WGVGSSKGRD RDFAFVASDK DSCMLKCHVF CCDVPAKAIA
   241  SALHGLCAQI LSERVEVSGD ASCCSPDPIS PEDLPRQVEL LDAVSQAAQK YEALYMGTLP
   301  VTKAMGMDVL NEAIGTLTAR GDRNAWVPTM LSVSDSLMTA HPIQAEASTE EEPLWQCPVR
   361  LVTFIGVGRD PHTFGLIADL GRQSFQCAAF WCQPHAGGLS EAVQAACMVQ YQKCLVASAA
   421  RGKAWGAQAR ARLRLKRTSS MDSPGGPLPL PLLKGGVGGA GATPRKRGVF SFLDAFRLKP
   481  SLLHMP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against APBB3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 24 nTPM
cerebral cortex: 15 nTPM
hypothalamus: 11 nTPM
pituitary gland: 10 nTPM
testis: 8.9 nTPM
hippocampal formation: 7.7 nTPM

Single-cell type

early spermatids: 68 nCPM
late spermatids: 61 nCPM
late primary spermatocytes: 35 nCPM
astrocytes: 32 nCPM
adrenal cortex cells: 31 nCPM
sertoli cells: 24 nCPM

Immune cell

basophil: 5.7 nTPM
neutrophil: 1.9 nTPM
intermediate monocyte: 1.8 nTPM
plasmacytoid DC: 1 nTPM
classical monocyte: 0.7 nTPM
gdT-cell: 0.7 nTPM

Brain region

cerebral cortex: 19 nTPM
hypothalamus: 18 nTPM
pons: 15 nTPM
cerebellum: 12 nTPM
basal ganglia: 12 nTPM
thalamus: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0
gnomAD missense Z: 0.81
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of APBB3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads APBB3 as an antibody target. Whether an autoantibody or antibody against APBB3 could matter depends on whether native APBB3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

APBB3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label APBB3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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