Dendritic Spine Regulation and Scaffold
IPR050889
Definition
The protein family is involved in various cellular functions, including the regulation of dendritic spine distribution and maintenance, acting as scaffolding proteins in dendritic spines, and participating in the ubiquitination and proteasomal degradation of target proteins. Members of the family are also implicated in translational fidelity, presynaptic neurotoxin activity, and endosome-to-plasma membrane trafficking. The family includes proteins that may serve as scaffold components in the postsynaptic density and are involved in the recruitment of vesicles to dendritic spines. Additionally, some members are associated with the inhibition of kinase activity under specific conditions and may lack ubiquitin-protein ligase activity in vitro.
7 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Loading the interactive Seroatlas explorer...