Seroatlas · Human Serome Atlas

IPO9

Importin-9

Also known as: FLJ10402, Imp9, IPO9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96P70
Gene: IPO9
Ensembl: ENSG00000198700
Chromosome: 1
Canonical length: 1041 aa
Protein class: Predicted intracellular proteins, Transporters
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables histone binding activity; histone chaperone activity; and nuclear import signal receptor activity. Involved in proteasome localization and protein import into nucleus. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1041 residues, UniProt reviewed canonical sequence.

>Q96P70|IPO9
     1  MAAAAAAGAA SGLPGPVAQG LKEALVDTLT GILSPVQEVR AAAEEQIKVL EVTEEFGVHL
    61  AELTVDPQGA LAIRQLASVI LKQYVETHWC AQSEKFRPPE TTERAKIVIR ELLPNGLRES
   121  ISKVRSSVAY AVSAIAHWDW PEAWPQLFNL LMEMLVSGDL NAVHGAMRVL TEFTREVTDT
   181  QMPLVAPVIL PEMYKIFTMA EVYGIRTRSR AVEIFTTCAH MICNMEELEK GAAKVLIFPV
   241  VQQFTEAFVQ ALQIPDGPTS DSGFKMEVLK AVTALVKNFP KHMVSSMQQI LPIVWNTLTE
   301  SAAFYVRTEV NYTEEVEDPV DSDGEVLGFE NLVFSIFEFV HALLENSKFK STVKKALPEL
   361  IYYIILYMQI TEEQIKVWTA NPQQFVEDED DDTFSYTVRI AAQDLLLAVA TDFQNESAAA
   421  LAAAATRHLQ EAEQTKNSGT EHWWKIHEAC MLALGSVKAI ITDSVKNGRI HFDMHGFLTN
   481  VILADLNLSV SPFLLGRALW AASRFTVAMS PELIQQFLQA TVSGLHETQP PSVRISAVRA
   541  IWGYCDQLKV SESTHVLQPF LPSILDGLIH LAAQFSSEVL NLVMETLCIV CTVDPEFTAS
   601  MESKICPFTI AIFLKYSNDP VVASLAQDIF KELSQIEACQ GPMQMRLIPT LVSIMQAPAD
   661  KIPAGLCATA IDILTTVVRN TKPPLSQLLI CQAFPAVAQC TLHTDDNATM QNGGECLRAY
   721  VSVTLEQVAQ WHDEQGHNGL WYVMQVVSQL LDPRTSEFTA AFVGRLVSTL ISKAGRELGE
   781  NLDQILRAIL SKMQQAETLS VMQSLIMVFA HLVHTQLEPL LEFLCSLPGP TGKPALEFVM
   841  AEWTSRQHLF YGQYEGKVSS VALCKLLQHG INADDKRLQD IRVKGEEIYS MDEGIRTRSK
   901  SAKNPERWTN IPLLVKILKL IINELSNVME ANAARQATPA EWSQDDSNDM WEDQEEEEEE
   961  EEDGLAGQLL SDILATSKYE EDYYEDDEED DPDALKDPLY QIDLQAYLTD FLCQFAQQPC
  1021  YIMFSGHLND NERRVLQTIG I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IPO9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

liver: 26 nTPM
cerebral cortex: 22 nTPM
choroid plexus: 22 nTPM
retina: 22 nTPM
cerebellum: 21 nTPM
blood vessel: 20 nTPM

Single-cell type

erythrocyte progenitors: 114 nCPM
adrenal cortex cells: 113 nCPM
myonuclei: 110 nCPM
corticotrophs: 108 nCPM
gonadotrophs: 107 nCPM
lactotrophs: 106 nCPM

Immune cell

non-classical monocyte: 14 nTPM
intermediate monocyte: 13 nTPM
myeloid DC: 13 nTPM
memory CD8 T-cell: 11 nTPM
basophil: 10 nTPM
classical monocyte: 10 nTPM

Brain region

cerebral cortex: 34 nTPM
cerebellum: 29 nTPM
hippocampal formation: 29 nTPM
hypothalamus: 29 nTPM
basal ganglia: 29 nTPM
amygdala: 29 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IPO9.

Disease | ImmuneIEDB

Conditions an epitope on IPO9 was assayed in.

ankylosing spondylitis T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.23
gnomAD pLI: 1
gnomAD missense Z: 3.28
DepMap mean gene effect: -0.6
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IPO9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IPO9 as an antibody target. Whether an autoantibody or antibody against IPO9 could matter depends on whether native IPO9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IPO9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IPO9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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