NFKBIZ

Protein identityUniProt · HPA

UniProt accession

Q9BYH8

Gene

NFKBIZ

Ensembl

ENSG00000144802

Chromosome

3

Canonical length

718 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nuclear speckles,Cytoplasmic bodies

OverviewNCBI Gene

This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

718 residues, UniProt reviewed canonical sequence.

>Q9BYH8|NFKBIZ
     1  MIVDKLLDDS RGGEGLRDAA GGCGLMTSPL NLSYFYGASP PAAAPGACDA SCSVLGPSAP
    61  GSPGSDSSDF SSASSVSSCG AVESRSRGGA RAERQPVEPH MGVGRQQRGP FQGVRVKNSV
   121  KELLLHIRSH KQKASGQAVD DFKTQGVNIE QFRELKNTVS YSGKRKGPDS LSDGPACKRP
   181  ALLHSQFLTP PQTPTPGESM EDVHLNEPKQ ESSADLLQNI INIKNECSPV SLNTVQVSWL
   241  NPVVVPQSSP AEQCQDFHGG QVFSPPQKCQ PFQVRGSQQM IDQASLYQYS PQNQHVEQQP
   301  HYTHKPTLEY SPFPIPPQSP AYEPNLFDGP ESQFCPNQSL VSLLGDQRES ENIANPMQTS
   361  SSVQQQNDAH LHSFSMMPSS ACEAMVGHEM ASDSSNTSLP FSNMGNPMNT TQLGKSLFQW
   421  QVEQEESKLA NISQDQFLSK DADGDTFLHI AVAQGRRALS YVLARKMNAL HMLDIKEHNG
   481  QSAFQVAVAA NQHLIVQDLV NIGAQVNTTD CWGRTPLHVC AEKGHSQVLQ AIQKGAVGSN
   541  QFVDLEATNY DGLTPLHCAV IAHNAVVHEL QRNQQPHSPE VQELLLKNKS LVDTIKCLIQ
   601  MGAAVEAKDR KSGRTALHLA AEEANLELIR LFLELPSCLS FVNAKAYNGN TALHVAASLQ
   661  YRLTQLDAVR LLMRKGADPS TRNLENEQPV HLVPDGPVGE QIRRILKGKS IQQRAPPY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NFKBIZ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.51

Highest tissue expression

384 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.19

gnomAD pLI

1

gnomAD missense Z

1.18

DepMap mean gene effect

-0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• B cell proliferation
• B cell receptor apoptotic signaling pathway
• cellular response to interleukin-17
• cellular response to lipopolysaccharide
• cellular response to transforming growth factor beta stimulus
• chromatin remodeling
• chronic inflammatory response
• cytokine-mediated signaling pathway
• defense response to Gram-negative bacterium
• epithelial cell apoptotic process
• establishment of skin barrier
• execution phase of apoptosis
• homeostasis of number of cells within a tissue
• inflammatory response to wounding
• isotype switching
• keratinocyte activation
• keratinocyte differentiation
• keratinocyte proliferation
• mRNA transcription by RNA polymerase II
• plasma cell differentiation
• positive regulation of inflammatory response
• positive regulation of T-helper 17 cell differentiation
• positive regulation of transcription by RNA polymerase II
• regulation of gene expression
• response to cisplatin
• response to folic acid
• response to Gram-positive bacterium
• response to xenobiotic stimulus
• spleen development
• T cell mediated immunity
• T cell receptor signaling pathway
• T-helper 1 cell differentiation
• T-helper 17 cell differentiation
• toll-like receptor signaling pathway
• transcription preinitiation complex assembly

Molecular functions

• POU domain binding
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• transcription coregulator activity

Cellular components

• cytoplasmic ribonucleoprotein granule
• nuclear speck
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Ankyrin repeat
• Ankyrin repeat-containing domain superfamily
• OCA domain
• Ankyrin repeats (3 copies)

KeywordsUniProt

• Activator
• ANK repeat
• Nucleus
• Repeat
• Repressor
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of NFKBIZ in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• AKIRIN2
• RELA
• NFKB1