Seroatlas · Human Serome Atlas

AKIRIN1

Akirin-1

Also known as: AKIR1_HUMAN, C1orf108, FLJ12666

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H9L7
Gene: AKIRIN1
Ensembl: ENSG00000174574
Chromosome: 1
Canonical length: 192 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear membrane

OverviewNCBI Gene

Predicted to enable transcription coregulator activity. Predicted to be involved in several processes, including myoblast migration involved in skeletal muscle regeneration; negative regulation of satellite cell differentiation; and positive regulation of lamellipodium assembly. Located in nuclear membrane and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

192 residues, UniProt reviewed canonical sequence.

>Q9H9L7|AKIRIN1
     1  MACGATLKRP MEFEAALLSP GSPKRRRCAP LPGPTPGLRP PDAEPPPPFQ TQTPPQSLQQ
    61  PAPPGSERRL PTPEQIFQNI KQEYSRYQRW RHLEVVLNQS EACASESQPH SSALTAPSSP
   121  GSSWMKKDQP TFTLRQVGII CERLLKDYED KIREEYEQIL NTKLAEQYES FVKFTHDQIM
   181  RRYGTRPTSY VS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AKIRIN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 79 nTPM

Expression across tissuesHPA

Tissue

testis: 79 nTPM
bone marrow: 73 nTPM
spinal cord: 53 nTPM
liver: 50 nTPM
adipose tissue: 43 nTPM
parathyroid gland: 41 nTPM

Single-cell type

early spermatids: 1,867 nCPM
late spermatids: 1,810 nCPM
late primary spermatocytes: 383 nCPM
platelets: 333 nCPM
neutrophils: 256 nCPM
syncytiotrophoblasts: 235 nCPM

Immune cell

neutrophil: 104 nTPM
eosinophil: 84 nTPM
NK-cell: 73 nTPM
naive CD4 T-cell: 64 nTPM
myeloid DC: 56 nTPM
T-reg: 55 nTPM

Brain region

hypothalamus: 104 nTPM
pons: 101 nTPM
white matter: 100 nTPM
medulla oblongata: 97 nTPM
midbrain: 96 nTPM
thalamus: 94 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.5
gnomAD pLI: 0.79
gnomAD missense Z: 0.5
DepMap mean gene effect: -0.35
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

transcription coregulator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Akirin

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AKIRIN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

AKIRIN2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AKIRIN1 as an antibody target. Whether an autoantibody or antibody against AKIRIN1 could matter depends on whether native AKIRIN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AKIRIN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AKIRIN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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