PCMT1

Protein identityUniProt · HPA

UniProt accession

P22061

Gene

PCMT1

Ensembl

ENSG00000120265

Chromosome

6

Canonical length

227 aa

Protein class

Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Cytosol

OverviewNCBI Gene

This gene encodes a member of the type II class of protein carboxyl methyltransferase enzymes. The encoded enzyme plays a role in protein repair by recognizing and converting D-aspartyl and L-isoaspartyl residues resulting from spontaneous deamidation back to the normal L-aspartyl form. The encoded protein may play a protective role in the pathogenesis of Alzheimer's disease, and single nucleotide polymorphisms in this gene have been associated with spina bifida and premature ovarian failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

227 residues, UniProt reviewed canonical sequence.

>P22061|PCMT1
     1  MAWKSGGASH SELIHNLRKN GIIKTDKVFE VMLATDRSHY AKCNPYMDSP QSIGFQATIS
    61  APHMHAYALE LLFDQLHEGA KALDVGSGSG ILTACFARMV GCTGKVIGID HIKELVDDSV
   121  NNVRKDDPTL LSSGRVQLVV GDGRMGYAEE APYDAIHVGA AAPVVPQALI DQLKPGGRLI
   181  LPVGPAGGNQ MLEQYDKLQD GSIKMKPLMG VIYVPLTDKE KQWSRWK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PCMT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.24

Highest tissue expression

207 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.46

gnomAD pLI

0.78

gnomAD missense Z

1.9

DepMap mean gene effect

-0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• protein methylation
• protein repair

Molecular functions

• cadherin binding
• protein-L-isoaspartate (D-aspartate) O-methyltransferase activity

Cellular components

• cytoplasm
• cytosol
• extracellular exosome
• extracellular vesicle

Protein domainsUniProt · Pfam · InterPro

• Protein-L-isoaspartate(D-aspartate) O-methyltransferase
• S-adenosyl-L-methionine-dependent methyltransferase superfamily
• Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

KeywordsUniProt

• Acetylation
• Cytoplasm
• Methyltransferase
• S-adenosyl-L-methionine
• Transferase

InteractionsUniProt · HPA

Protein binding partners of PCMT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• EIF4EBP2
• AIMP2
• RPIA