TARS3

Protein identityUniProt · HPA

UniProt accession

A2RTX5

Gene

TARS3

Ensembl

ENSG00000185418

Chromosome

15

Canonical length

802 aa

Protein class

Enzymes, Predicted intracellular proteins

Subcellular location

Cytosol

OverviewNCBI Gene

Predicted to enable threonine-tRNA ligase activity. Predicted to be involved in threonyl-tRNA aminoacylation. Predicted to be located in cytoplasm and nucleus. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

802 residues, UniProt reviewed canonical sequence.

>A2RTX5|TARS3
     1  MAAEALAAEA VASRLERQEE DIRWLWSEVE RLRDEQLNAP YSCQAEGPCL TREVAQLRAE
    61  NCDLRHRLCS LRLCLAEERS RQATLESAEL EAAQEAGAQP PPSQSQDKDM KKKKMKESEA
   121  DSEVKHQPIF IKERLKLFEI LKKDHQLLLA IYGKKGDTSN IITVRVADGQ TVQGEVWKTT
   181  PYQVAAEISQ ELAESTVIAK VNGELWDLDR PLEGDSSLEL LTFDNEEAQA VYWHSSAHIL
   241  GEAMELYYGG HLCYGPPIEN GFYYDMFIED RAVSSTELSA LENICKAIIK EKQPFERLEV
   301  SKEILLEMFK YNKFKCRILN EKVNTATTTV YRCGPLIDLC KGPHVRHTGK IKTIKIFKNS
   361  STYWEGNPEM ETLQRIYGIS FPDNKMMRDW EKFQEEAKNR DHRKIGKEQE LFFFHDLSPG
   421  SCFFLPRGAF IYNTLTDFIR EEYHKRDFTE VLSPNMYNSK LWEASGHWQH YSENMFTFEI
   481  EKDTFALKPM NCPGHCLMFA HRPRSWREMP IRFADFGVLH RNELSGTLSG LTRVRRFQQD
   541  DAHIFCTVEQ IEEEIKGCLQ FLQSVYSTFG FSFQLNLSTR PENFLGEIEM WNEAEKQLQN
   601  SLMDFGEPWK MNPGDGAFYG PKIDIKIKDA IGRYHQCATI QLDFQLPIRF NLTYVSKDGD
   661  DKKRPVIIHR AILGSVERMI AILSENYGGK WPFWLSPRQV MVIPVGPTCE KYALQVSSEF
   721  FEEGFMADVD LDHSCTLNKK IRNAQLAQYN FILVVGEKEK IDNAVNVRTR DNKIHGEILV
   781  TSAIDKLKNL RKTRTLNAEE AF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TARS3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

36 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.9

gnomAD pLI

0

DepMap mean gene effect

0

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• threonyl-tRNA aminoacylation

Molecular functions

• ATP binding
• threonine-tRNA ligase activity

Cellular components

• cytoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)
• Threonine-tRNA ligase, class IIa
• TGS
• Anticodon-binding
• Aminoacyl-tRNA synthetase, class II
• Beta-grasp domain superfamily
• TGS-like
• Threonyl/alanyl tRNA synthetase, SAD
• Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily
• Threonine-tRNA ligase catalytic core domain
• Anticodon-binding domain superfamily
• Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)
• Threonine-tRNA ligase, class IIa, anticodon-binding domain
• tRNA synthetase class II core domain (G, H, P, S and T)
• TGS domain
• Anticodon binding domain
• Threonyl and Alanyl tRNA synthetase second additional domain

KeywordsUniProt

• Acetylation
• Aminoacyl-tRNA synthetase
• ATP-binding
• Coiled coil
• Cytoplasm
• Ligase
• Nucleotide-binding
• Nucleus
• Phosphoprotein
• Protein biosynthesis

InteractionsUniProt · HPA

Protein binding partners of TARS3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• AIMP1
• AIMP2
• KARS1
• EPRS1
• TARS1