MYM-type Zinc finger with FCS sequence motif

Definition

MYM-type zinc fingers were identified in MYM family proteins PMID:9716603. Human protein [swissprot:Q14202] is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1 PMID:8817323. [swissprot:Q9UBW7] is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1 PMID:9576949; in atypical myeloproliferative disorders it is rearranged PMID:9694738. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons PMID:11689653.

7 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (7 proteins: gene, accession, name)

• SOBP
• ZMYM1
• ZMYM2
• ZMYM3
• ZMYM4
• ZMYM5
• ZMYM6