Seroatlas · Human Serome Atlas

ZMYM4

Zinc finger MYM-type protein 4

Also known as: KIAA0425, MYM, ZMYM4_HUMAN, ZNF198L3, ZNF262

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VZL5
Gene: ZMYM4
Ensembl: ENSG00000146463
Chromosome: 1
Canonical length: 1548 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

Predicted to enable DNA binding activity. Involved in cytoskeleton organization and regulation of cell morphogenesis. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1548 residues, UniProt reviewed canonical sequence.

>Q5VZL5|ZMYM4
     1  MAEREVESGP RKRFEQKSGA VFDEIVENCG GIMDTEMSED IDHNLTPTLD SMSYGMPNQT
    61  GSENSLLDED DYFLNSGDLA GIPVVGSDNE DEQDFSSKDN LVSSIHTDDS LEVERRVTQH
   121  ESDNENEIQI QNKLKKDFPK QFDQVSVFKS IRKDFSLVRE NSKETFSGKE KNRDLTYERE
   181  KRLDKPHKDL DSRLKSSFFD KAANQVEETL HTHLPQTPET NFRDSSYPFA NKESIGSELG
   241  NSFASNIRIK EEPLDDEYDK AMAPQQGLLD KIKDEPDNAQ EYSHGQQQKT QEGELKISAV
   301  FSVSGSPLAP QLTTGFQPSL ASSGMNKMLP SVPATAVRVS CSGCKKILQK GQTAYQRKGS
   361  TQLFCSTLCL TGYTVPPARP PPPLTKKTCS SCSKDILNPK DVISAQFENT TTSKDFCSQS
   421  CLSTYELKKK PIVTINTNSI STKCSMCQKN AVIRHEVNYQ NVVHKLCSDA CFSKFRSANN
   481  LTMNCCENCG GYCYSGSGQC HMLQIEGQSK KFCSSSCITA YKQKSAKITP CALCKSLRSS
   541  AEMIENTNSL GKTELFCSVN CLSAYRVKMV TSAGVQVQCN SCKTSAIPQY HLAMSDGSIR
   601  NFCSYSCVVA FQNLFNKPTG MNSSVVPLSQ GQVIVSIPTG STVSAGGGST SAVSPTSISS
   661  SAAAGLQRLA AQSQHVGFAR SVVKLKCQHC NRLFATKPEL LDYKGKMFQF CGKNCSDEYK
   721  KINNVMAMCE YCKIEKIVKE TVRFSGADKS FCSEGCKLLY KHDLAKRWGN HCKMCSYCLQ
   781  TSPKLVQNNL GGKVEEFCCE ECMSKYTVLF YQMAKCDACK RQGKLSESLK WRGEMKHFCN
   841  LLCILMFCNQ QSVCDPPSQN NAANISMVQA ASAGPPSLRK DSTPVIANVV SLASAPAAQP
   901  TVNSNSVLQG AVPTVTAKII GDASTQTDAL KLPPSQPPRL LKNKALLCKP ITQTKATSCK
   961  PHTQNKECQT EDTPSQPQII VVPVPVPVFV PIPLHLYTQY APVPFGIPVP MPVPMLIPSS
  1021  MDSEDKVTES IEDIKEKLPT HPFEADLLEM AEMIAEDEEK KTLSQGESQT SEHELFLDTK
  1081  IFEKDQGSTY SGDLESEAVS TPHSWEEELN HYALKSNAVQ EADSELKQFS KGETEQDLEA
  1141  DFPSDSFDPL NKGQGIQARS RTRRRHRDGF PQPRRRGRKK SIVAVEPRSL IQGAFQGCSV
  1201  SGMTLKYMYG VNAWKNWVQW KNAKEEQGDL KCGGVEQASS SPRSDPLGST QDHALSQESS
  1261  EPGCRVRSIK LKEDILSCTF AELSLGLCQF IQEVRRPNGE KYDPDSILYL CLGIQQYLFE
  1321  NGRIDNIFTE PYSRFMIELT KLLKIWEPTI LPNGYMFSRI EEEHLWECKQ LGAYSPIVLL
  1381  NTLLFFNTKY FQLKNVTEHL KLSFAHVMRR TRTLKYSTKM TYLRFFPPLQ KQESEPDKLT
  1441  VGKRKRNEDD EVPVGVEMAE NTDNPLRCPV RLYEFYLSKC SESVKQRNDV FYLQPERSCV
  1501  PNSPMWYSTF PIDPGTLDTM LTRILMVREV HEELAKAKSE DSDVELSD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZMYM4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

testis: 32 nTPM
retina: 23 nTPM
ovary: 20 nTPM
thymus: 19 nTPM
thyroid gland: 17 nTPM
parathyroid gland: 17 nTPM

Single-cell type

sertoli cells: 337 nCPM
podocytes: 335 nCPM
choroid plexus epithelial cells: 318 nCPM
myonuclei: 290 nCPM
pituicytes/fscs: 268 nCPM
oligodendrocyte progenitor cells: 266 nCPM

Immune cell

non-classical monocyte: 7.2 nTPM
plasmacytoid DC: 7 nTPM
NK-cell: 6.7 nTPM
intermediate monocyte: 5.1 nTPM
classical monocyte: 3.6 nTPM
myeloid DC: 3.6 nTPM

Brain region

cerebellum: 60 nTPM
white matter: 42 nTPM
cerebral cortex: 42 nTPM
hypothalamus: 41 nTPM
thalamus: 41 nTPM
spinal cord: 40 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZMYM4.

Disease | ImmuneIEDB

Conditions an epitope on ZMYM4 was assayed in.

skin melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.18
gnomAD pLI: 1
gnomAD missense Z: 3.86
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZMYM4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZMYM4 as an antibody target. Whether an autoantibody or antibody against ZMYM4 could matter depends on whether native ZMYM4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZMYM4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZMYM4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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