Seroatlas · Human Serome Atlas

ZMYM5

Zinc finger MYM-type protein 5

Also known as: MYM, ZMYM5_HUMAN, ZNF198L1, ZNF237

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UJ78
Gene: ZMYM5
Ensembl: ENSG00000132950
Chromosome: 13
Canonical length: 669 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

669 residues, UniProt reviewed canonical sequence.

>Q9UJ78|ZMYM5
     1  MEKCSVGGLE LTEQTPALLG NMAMATSLMD IGDSFGHPAC PLVSRSRNSP VEDDDDDDDV
    61  VFIESIQPPS ISAPAIADQR NFIFASSKNE KPQGNYSVIP PSSRDLASQK GNISETIVID
   121  DEEDIETNGG AEKKSSCFIE WGLPGTKNKT NDLDFSTSSL SRSKTKTGVR PFNPGRMNVA
   181  GDLFQNGEFA THHSPDSWIS QSASFPSNQK QPGVDSLSPV ALLRKQNFQP TAQQQLTKPA
   241  KITCANCKKP LQKGQTAYQR KGSAHLFCST TCLSSFSHKR TQNTRSIICK KDASTKKANV
   301  ILPVESSKSF QEFYSTSCLS PCENNWNLKK GVFNKSRCTI CSKLAEIRHE VSVNNVTHKL
   361  CSNHCFNKYR LANGLIMNCC EHCGEYMPSK STGNNILVIG GQQKRFCCQS CINEYKQMME
   421  TKSKKLTASE NRKRNAFREE NEKQLYGSSN TLLKKIEGIP EKKEKTSQLQ LSVECGTDTL
   481  LIQENVNLPP SSTSTIADTF QEQLEEKNFE DSIVPVVLSA DPGTWPRILN IKQRDTLVEN
   541  VPPQVRNFNF PKDNTGRKFS ETYYTRILPN GEKTTRSWLL YSTSKDSVFC LYCKLFGEGK
   601  NQLKNENGCK DWQHLSHILS KHEESEMHVN NSVKYSKLKS DLKKNKAIDA AEHRLYENEK
   661  NDGVLLLYT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZMYM5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

testis: 22 nTPM
bone marrow: 12 nTPM
lymph node: 9.6 nTPM
thymus: 9.4 nTPM
gallbladder: 8.6 nTPM
retina: 8.4 nTPM

Single-cell type

thymocytes: 160 nCPM
early primary spermatocytes: 130 nCPM
ocular epithelial cells: 105 nCPM
neutrophils: 99 nCPM
adrenal cortex cells: 95 nCPM
choroid plexus epithelial cells: 91 nCPM

Immune cell

basophil: 16 nTPM
neutrophil: 11 nTPM
memory B-cell: 9.9 nTPM
memory CD4 T-cell: 9.9 nTPM
MAIT T-cell: 9.3 nTPM
T-reg: 8.9 nTPM

Brain region

white matter: 13 nTPM
choroid plexus: 11 nTPM
medulla oblongata: 11 nTPM
basal ganglia: 9.8 nTPM
thalamus: 9.8 nTPM
cerebellum: 9.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.04
gnomAD pLI: 0
gnomAD missense Z: -0.06
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZMYM5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SUMO1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZMYM5 as an antibody target. Whether an autoantibody or antibody against ZMYM5 could matter depends on whether native ZMYM5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZMYM5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZMYM5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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