Seroatlas · Human Serome Atlas

ZMYM2

Zinc finger MYM-type protein 2

Also known as: FIM, MYM, RAMP, ZMYM2_HUMAN, ZNF198

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UBW7
Gene: ZMYM2
Ensembl: ENSG00000121741
Chromosome: 13
Canonical length: 1377 aa
Protein class: Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Endoplasmic reticulum
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a zinc finger protein that may act as a transcription factor. The encoded protein may be part of a BHC histone deacetylase complex. Translocation of this gene with the fibroblast growth factor receptor-1 gene (FGFR1) results in a fusion gene, which may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]

Canonical amino-acid sequenceUniProt

1377 residues, UniProt reviewed canonical sequence.

>Q9UBW7|ZMYM2
     1  MDTSSVGGLE LTDQTPVLLG STAMATSLTN VGNSFSGPAN PLVSRSNKFQ NSSVEDDDDV
    61  VFIEPVQPPP PSVPVVADQR TITFTSSKNE ELQGNDSKIT PSSKELASQK GSVSETIVID
   121  DEEDMETNQG QEKNSSNFIE RRPPETKNRT NDVDFSTSSF SRSKVNAGMG NSGITTEPDS
   181  EIQIANVTTL ETGVSSVNDG QLENTDGRDM NLMITHVTSL QNTNLGDVSN GLQSSNFGVN
   241  IQTYTPSLTS QTKTGVGPFN PGRMNVAGDV FQNGESATHH NPDSWISQSA SFPRNQKQPG
   301  VDSLSPVASL PKQIFQPSVQ QQPTKPVKVT CANCKKPLQK GQTAYQRKGS AHLFCSTTCL
   361  SSFSHKPAPK KLCVMCKKDI TTMKGTIVAQ VDSSESFQEF CSTSCLSLYE DKQNPTKGAL
   421  NKSRCTICGK LTEIRHEVSF KNMTHKLCSD HCFNRYRMAN GLIMNCCEQC GEYLPSKGAG
   481  NNVLVIDGQQ KRFCCQSCVS EYKQVGSHPS FLKEVRDHMQ DSFLMQPEKY GKLTTCTGCR
   541  TQCRFFDMTQ CIGPNGYMEP YCSTACMNSH KTKYAKSQSL GIICHFCKRN SLPQYQATMP
   601  DGKLYNFCNS SCVAKFQALS MQSSPNGQFV APSDIQLKCN YCKNSFCSKP EILEWENKVH
   661  QFCSKTCSDD YKKLHCIVTY CEYCQEEKTL HETVNFSGVK RPFCSEGCKL LYKQDFARRL
   721  GLRCVTCNYC SQLCKKGATK ELDGVVRDFC SEDCCKKFQD WYYKAARCDC CKSQGTLKER
   781  VQWRGEMKHF CDQHCLLRFY CQQNEPNMTT QKGPENLHYD QGCQTSRTKM TGSAPPPSPT
   841  PNKEMKNKAV LCKPLTMTKA TYCKPHMQTK SCQTDDTWRT EYVPVPIPVP VYIPVPMHMY
   901  SQNIPVPTTV PVPVPVPVFL PAPLDSSEKI PAAIEELKSK VSSDALDTEL LTMTDMMSED
   961  EGKTETTNIN SVIIETDIIG SDLLKNSDPE TQSSMPDVPY EPDLDIEIDF PRAAEELDME
  1021  NEFLLPPVFG EEYEEQPRPR SKKKGAKRKA VSGYQSHDDS SDNSECSFPF KYTYGVNAWK
  1081  HWVKTRQLDE DLLVLDELKS SKSVKLKEDL LSHTTAELNY GLAHFVNEIR RPNGENYAPD
  1141  SIYYLCLGIQ EYLCGSNRKD NIFIDPGYQT FEQELNKILR SWQPSILPDG SIFSRVEEDY
  1201  LWRIKQLGSH SPVALLNTLF YFNTKYFGLK TVEQHLRLSF GTVFRHWKKN PLTMENKACL
  1261  RYQVSSLCGT DNEDKITTGK RKHEDDEPVF EQIENTANPS RCPVKMFECY LSKSPQNLNQ
  1321  RMDVFYLQPE CSSSTDSPVW YTSTSLDRNT LENMLVRVLL VKDIYDKDNY ELDEDTD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZMYM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

testis: 46 nTPM
bone marrow: 25 nTPM
retina: 24 nTPM
thyroid gland: 23 nTPM
thymus: 20 nTPM
tongue: 19 nTPM

Single-cell type

sertoli cells: 779 nCPM
adrenal cortex cells: 514 nCPM
pituicytes/fscs: 486 nCPM
somatotrophs: 470 nCPM
lactotrophs: 443 nCPM
thymocytes: 413 nCPM

Immune cell

neutrophil: 3.8 nTPM
naive CD4 T-cell: 3.7 nTPM
memory CD4 T-cell: 3.6 nTPM
MAIT T-cell: 3.4 nTPM
naive CD8 T-cell: 3.3 nTPM
plasmacytoid DC: 3.3 nTPM

Brain region

white matter: 59 nTPM
choroid plexus: 55 nTPM
cerebral cortex: 55 nTPM
basal ganglia: 52 nTPM
thalamus: 51 nTPM
hypothalamus: 51 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZMYM2.

Disease | AllUniProt

Conditions ZMYM2 is implicated in, by any mechanism.

Neurodevelopmental-craniofacial syndrome with variable renal and cardiac abnormalities (NECRC) MIM:619522

Disease | GeneticClinVar

106 pathogenic / likely-pathogenic of 430 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Neurodevelopmental-craniofacial syndrome with variable renal and cardiac abnormalities
Congenital anomaly of kidney and urinary tract
Inborn genetic diseases
ZMYM2-related disorder
Neurodevelopmental disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.33
gnomAD pLI: 0.67
gnomAD missense Z: 3.01
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of DNA-templated transcription

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZMYM2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZMYM2 as an antibody target. Whether an autoantibody or antibody against ZMYM2 could matter depends on whether native ZMYM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZMYM2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZMYM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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