Diacylglycerol acyltransferase
PF03982
Definition
The terminal step of triacylglycerol (TAG) formation is catalysed by the enzyme diacylglycerol acyltransferase (DAGAT), required for synthesis and storage of intracellular triglycerides [[cite:PMID:11751875],[cite:PMID:11751830],[cite:PMID:27184406]]. In yeast, it is involved in lipid particle synthesis from the endoplasmic reticulum (ER), promoting localised TAG production at discrete ER subdomains, and in ergosterol biosynthesis [[cite:PMID:11751875],[cite:PMID:12963726]]. This family also includes Acyl-CoA wax alcohol acyltransferase 1 and 2 (AWAT1/2) which catalyse the formation of ester bonds between fatty alcohols and fatty acyl-CoAs to form wax monoesters [[cite:PMID:15671038],[cite:PMID:28420705]]. AWAT2 (also known as MFAT) also possesses acyl-CoA retinol acyltransferase (ARAT) activity that catalyses 11-cis-specific retinyl ester synthesis and shows higher catalytic efficiency toward 11-cis-retinol versus 9-cis-retinol, 13-cis-retinol, and all-trans-retinol substrates PMID:24799687.
7 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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